Good long-term outcomes for drug-eluting stents

April 4, 2012
Good long-Term outcomes for drug-Eluting stents
Meta-analysis of randomized clinical trials suggests that drug-eluting stents (DESs) significantly reduce repeat revascularizations, with no increase in stent thrombosis (ST), mortality, or recurrent myocardial infarction, but data from observational studies indicate an increased risk of ST with DES use, according to research published in the April 1 issue of The American Journal of Cardiology.

(HealthDay) -- Meta-analysis of randomized clinical trials (RCTs) suggests that drug-eluting stents (DESs) significantly reduce repeat revascularizations, with no increase in stent thrombosis (ST), mortality, or recurrent myocardial infarction, but data from observational studies indicate an increased risk of ST with DES use, according to research published in the April 1 issue of The American Journal of Cardiology.

To investigate the long-term outcomes of DESs and bare metal stents (BMSs) after primary (PPCI), Eric L. Wallace, D.O., of the University of Kentucky in Lexington, and associates conducted a meta-analysis of eight RCTs involving 5,797 patients and five with 4,650 patients.

In the RCTs, the researchers found that patients receiving sirolimus- or paclitaxel-eluting stents, compared with BMSs, had a significantly lower risk of target lesion revascularization (odds ratio [OR], 0.48), target vessel revascularization (OR, 0.53), and major adverse cardiac events (OR, 0.69). ST, mortality, and recurrent were not significantly different between the groups. In the observational studies, at three or more years follow-up, there was a small but significant increase in ST with DES use (OR, 1.62), with no evidence of recurrent myocardial infarction. DES use was associated with significantly reduced mortality compared with BMS use (OR, 0.65).

"This meta-analysis of RCTs examining the long-term outcomes of first-generation DESs versus BMSs in PPCI, DES use resulted in decreased repeat revascularization with no increase in ST, mortality, or recurrent myocardial infarction," the authors write. "The meta-analysis of observational studies demonstrates a small increase in the risk of ST and improved survival associated with DES use."

Explore further: Results of the DEB-AMI Trial reported at TCT 2011

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Results of the DEB-AMI Trial reported at TCT 2011

November 10, 2011
A clinical trial that compared the use of drug-eluting balloons (DEB) and bare metal stents (BMS) to both bare metal stents alone and drug-eluting stents (DES) found that the drug-eluting balloon group did not meet the primary ...

Recommended for you

Laser device placed on the heart identifies insufficient oxygenation better than other measures

September 20, 2017
A new device can assess in real time whether the body's tissues are receiving enough oxygen and, placed on the heart, can predict cardiac arrest in critically ill heart patients, report researchers at Boston Children's Hospital ...

Metabolism switch signals end for healing hearts

September 19, 2017
Researchers have identified the process that shuts down the human heart's ability to heal itself, and are now searching for a drug to reverse it.

Beta blockers not needed after heart attack if other medications taken

September 18, 2017
A new study from the University of North Carolina at Chapel Hill finds beta blockers are not needed after a heart attack if heart-attack survivors are taking ACE inhibitors and statins. The study is the first to challenge ...

Which single behavior best prevents high blood pressure?

September 15, 2017
(HealthDay)—You probably already know that certain healthy lifestyle behaviors can reduce your risk of developing high blood pressure, but is any one behavior more important than the others?

RESPECT trial shows closing a small hole in heart may protect against recurrent stroke

September 13, 2017
A device used to close a small hole in the heart may benefit certain stroke patients by providing an extra layer of protection for those facing years of ongoing stroke risk, according to the results of a large clinical trial ...

Study shows so-called 'healthy obesity' is harmful to cardiovascular health

September 11, 2017
Clinicians are being warned not to ignore the increased cardiovascular health risks of those who are classed as either 'healthy obese' or deemed to be 'normal weight' but have metabolic abnormalities such as diabetes.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.