This article has been reviewed according to Science X's editorial process and policies. Editors have highlighted the following attributes while ensuring the content's credibility:


peer-reviewed publication

trusted source


Intervention in Navajo Nation boosts uptake for heart failure drugs by 53%

navajo nation
Credit: Unsplash/CC0 Public Domain

A team led by LDI senior fellow and Perelman School of Medicine faculty member Lauren Eberly at a Navajo Nation hospital in New Mexico has developed a simple intervention that increased the uptake of guideline-directed heart failure therapy drugs by 53%. Titled "Telephone-Based Guideline-Directed Medical Therapy Optimization in Navajo Nation: The Hózhó Randomized Clinical Trial," the study is published in the April issue of JAMA Internal Medicine.

"We found a 53% increase in the uptake of guideline-directed medical therapy to be a very significant effect," said Eberly. "In some ways, the magnitude of the effect was surprising, but in many ways, it was not surprising in how it speaks to the importance of designing an intervention that centers the community perspective and needs."

Part of an Indian Health Service (IHS) Innovations Award supported by the IHS headquarters Office of Quality, the study was done at the Gallup Indian Medical Center in New Mexico. The tested intervention was built around a telehealth-based strategy for remote initiation and titration of appropriate guideline-directed drug therapies for patients with with reduced ejection fraction. That means their heart was pumping insufficient amounts of blood in relation to their body's minimal needs.

In this five-minute video LDI Senior Fellow Lauren Eberly details her latest study on the Navajo Nation reservation in New Mexico. Credit: University of Pennsylvania

High rates of heart failure

"Heart failure is a major cause of morbidity and mortality for our patient population in Eastern Navajo Nation," said Eberly. "Unfortunately, the of the American Indian and Alaska Native population has really been under prioritized and is severely understudied. Therefore, there's really a paucity of data regarding cardiovascular disease burden and outcomes in this population."

"From some of our prior work, we know that among elderly American Indian and Alaska Native patients with Medicare nationally, the prevalence of heart failure is nearly 30%," Eberly continued. "That's incredibly high. Prior studies of these same groups also showed the incidence of coronary artery disease, which is a major cause of heart failure, is double that of other in the United States."

In Navajo Nation, overall health issues are compounded by the fact that many residential areas lack electricity or running water and are located along remote rural roads that are often impassable in winter.

The goal of the IHS Innovations Award study was to identify and address the major barriers to heart failure care throughout the Eastern section of the larger Navajo reservation that sprawls across 27,000 square miles of New Mexico, Arizona and Utah and is home to 167,000 people.

Racial inequities

"The background of our work was that guideline-directed for heart failure saves lives and really improves quality of life for patients," said Eberly. "However, nationally, these medicines are really underutilized, and we know that racial inequities in their use have been well documented. There's also really been a paucity of efforts designed specifically to improve uptake of these therapies for racially marginalized patient groups, and particularly for American Indian patients."

In close collaboration with the Navajo community and clinicians, the research team determined that the clinical barriers to the uptake of recommended heart failure therapies were clinical burden, , lack of comfort with newer heart failure therapies, and lack of comfort with newer clinical guidelines.

The main patient barriers to treatment were transportation and clinician availability.

Limited broadband

"We worked with patients and community advisors to design a telehealth model in a reservation environment where there is limited broadband," said Eberly. "Phone calls were really the optimal telehealth modality."

The intervention was simple and targeted patients who had previously received an echocardiogram estimate of their heart pumping function. They would come into the hospital to pick up a blood pressure cuff.

Research team members would review their medicine regimen to identify and prescribe any missing drug therapy over the phone. Over the next month, the patient would be contacted by phone multiple times at home for blood pressure readings that would be used to adjust the drug dosage over the phone. The goal was to optimize the patient's heart failure regimen by the end of 30 days.

Aside from the greatly increased use of guideline-directed therapy in the study group, the research found that the telehealth intervention also reduced the rate of the participants' heart failure hospitalizations.

Combat structural racism

"Our strategy leveraged the electronic health record on a health system level to identify patients not receiving appropriate therapy, and subsequently optimize therapy without relying on in-person visits for specialty care," said Eberly. "We believe that such models can advance equity and combat structural racism in cardiovascular care."

Eberly, a staff cardiologist at the Gallup Indian Medical Center, is also an Assistant Professor of Medicine in the Penn Medicine Division of Cardiovascular Medicine and a resident in the Penn Global Health Equities Track program that nurtures and trains health professionals to focus their careers on addressing health disparities domestically or globally.

"Back when I was raised in New Mexico, I saw firsthand the impact of poverty on health," Eberly explained. "I was drawn to medicine because I saw it could be an incredible tool to advance justice."

She has previously served with Partners in Health in Rwanda and Liberia, assisting with the implementation of nurse-driven care delivery models for noncommunicable diseases, with a special focus on heart failure.

Eberly earned her MD at the University of New Mexico School of Medicine and her MPH from the Harvard School of Public Health.

More information: Lauren A. Eberly et al, Telephone-Based Guideline-Directed Medical Therapy Optimization in Navajo Nation, JAMA Internal Medicine (2024). DOI: 10.1001/jamainternmed.2024.1523

Journal information: JAMA Internal Medicine
Citation: Intervention in Navajo Nation boosts uptake for heart failure drugs by 53% (2024, May 8) retrieved 14 July 2024 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Burden of heart disease considerable for American Indians, Alaska natives


Feedback to editors