Fecal calprotectin levels ID severity of Crohn's in small bowel

December 26, 2016

(HealthDay)—Fecal calprotectin (FC) levels correlate with the severity of Crohn's disease (CD) of the small bowel, as identified by balloon-assisted enteroscopy and computed tomography enterography (CTE), according to a study published in the January issue of Clinical Gastroenterology and Hepatology.

Tsunetaka Arai, from the Toho University Sakura Medical Center in Japan, and colleagues conducted a prospective study involving 123 patients with CD (35 with ileitis, 72 with ileocolitis, and 16 with colitis) who underwent balloon-assisted enteroscopy from May 2012 through July 2015. Seventeen patients with balloon-assisted enteroscopy-detected strictures underwent CTE evaluation. A CTE scoring system was developed for .

The researchers observed a correlation between the level of FC and the simple endoscopic index for CD score, even among patients with only active disease of the small intestine. In the 17 patients with strictures that could not be passed with the enteroscope, CTE detected all lesions beyond the strictures and those in areas in the distal sides of the strictures. In these patients there was a correlation between the level of FC and CTE. The FC cut-off for mucosal healing was 215 µg/g in receiver operating characteristic analyses, which identified patients with healing with a sensitivity and specificity of 82.8 and 71.4 percent, respectively.

"A combination of measurement of level of FC and CTE appears to be effective for monitoring CD activity in with small intestinal CD," the authors write.

Explore further: New guideline addresses male urethral stricture

More information: Full Text (subscription or payment may be required)

Related Stories

New guideline addresses male urethral stricture

December 21, 2016
(HealthDay)—A new guideline by the American Urological Association, published in the January issue of The Journal of Urology, provides a clinical framework for the diagnosis and treatment of male urethral stricture.

Study examining large-scale data of double balloon enteroscopy shows it is safe and effective

September 26, 2011
A large-scale data review by researchers in China of double balloon enteroscopy (DBE) over the last decade showed the endoscopic procedure to be safe and effective for detection of diseases of the small intestine. DBE had ...

New approach to preventing fibrosing strictures in IBD

January 15, 2015
A natural protein made by immune cells may limit fibrosis and scarring in colitis, according to research published in the inaugural issue of Cellular and Molecular Gastroenterology and Hepatology, the new basic science journal ...

Patient factors affect accuracy of AFP detection of liver cancer

May 4, 2014
(HealthDay)—Measurement of α-fetoprotein (AFP) detects hepatocellular carcinoma (HCC) most accurately in patients without hepatitis C virus (HCV) infection, according to a study published in the May issue of Clinical Gastroenterology ...

Ultrashort echo-time MRI IDs lung abnormalities in CF

September 2, 2016
(HealthDay)—For children with cystic fibrosis (CF), ultrashort echo-time (UTE) magnetic resonance imaging (MRI) can detect structural lung disease, according to a study published online Aug. 23 in the Annals of the American ...

Recommended for you

Why do women get more migraines?

August 14, 2018
Research published today reveals a potential mechanism for migraine causation which could explain why women get more migraines than men. The study, in Frontiers in Molecular Biosciences, suggests that sex hormones affect ...

Link between common 'harmless' virus and cardiovascular damage

August 13, 2018
Researchers from Brighton and Sussex Medical School (BSMS) have found an unexpectedly close link between a herpes virus and the occurrence of immune cells damaging cardiovascular tissue.

Rotavirus vaccine cuts infant diarrhoea deaths by a third in Malawi

August 11, 2018
A major new study has shown that rotavirus vaccination reduced infant diarrhoea deaths by 34% in rural Malawi, a region with high levels of child deaths.

Experts highlight Ebola vaccine progress and suggest next steps

August 11, 2018
Despite promising advances, important scientific questions remain unanswered in the effort to develop a safe and effective Ebola vaccine, according to members of an international Ebola research consortium. In a Viewpoint ...

Ebola virus experts discover powerful, new approach for future therapeutics

August 9, 2018
A one-two punch of powerful antibodies may be the best way to stop Ebola virus, reports an international team of scientists in the journal Cell. Their findings suggest new therapies should disable Ebola virus's infection ...

Changes in gut microbiome in only one subset of helminth-infected patients

August 9, 2018
Over the last decade, it's become clearer than ever that bacteria in the human gut— collectively termed the microbiome—play a key role in health and disease. Now, researchers reporting in PLOS Neglected Tropical Diseases ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.