Patient factors affect accuracy of AFP detection of liver cancer

May 4, 2014
Patient factors affect accuracy of AFP detection of liver cancer

(HealthDay)—Measurement of α-fetoprotein (AFP) detects hepatocellular carcinoma (HCC) most accurately in patients without hepatitis C virus (HCV) infection, according to a study published in the May issue of Clinical Gastroenterology and Hepatology.

Purva Gopal, M.D., from the University of Texas Southwestern Medical Center in Dallas, and colleagues analyzed data from with cirrhosis (with [452 patients] or without [676 patients] HCC) from January 2005 through June 2012. Levels of AFP were calculated that would detect HCC with the highest levels of sensitivity and specificity in subgroups using receiver operator characteristic analysis.

The researchers found that levels of AFP >20 ng/mL detected HCC with 70.1 percent sensitivity and 89.8 percent specificity. Patients with HCC were identified with this AFP level with a c-statistic of 0.87, but it was significantly more accurate in HCV-negative patients than in HCV-positive patients (P = 0.007). HCC in patients with HCV-associated cirrhosis was most accurately detected with AFP levels ≥59 ng/mL, while levels of AFP ≥11 ng/mL accurately identified HCC in HCV-negative patients.

"Based on a retrospective analysis of data from patients with cirrhosis, with or without HCC, AFP level most accurately detects HCC in patients without HCV infection," the authors write.

Explore further: Screening for liver cancer in patients with cirrhosis

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Screening for liver cancer in patients with cirrhosis

April 1, 2014

In a systematic review and meta-analysis of 47 studies with 15,158 patients, Amit Singal (University of Texas Southwestern Medical Center) and colleagues found that patients with cirrhosis who underwent surveillance (via ...

Better long-term outcomes with low hep C viral load

March 25, 2013

(HealthDay)—In patients with hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC), low HCV viral load predicts better long-term surgical outcomes, regardless of the serologic eradication of HCV, according to research ...

Hepatic decompensation higher with HIV, HCV co-infection

March 18, 2014

(HealthDay)—Patients co-infected with HIV and hepatitis C virus (HCV) have higher rates of hepatic decompensation than those with HCV monoinfection, according to a study published in the March 18 issue of the Annals of ...

Recommended for you

Dogs detect breast cancer from bandage: researchers

March 24, 2017

Dogs can sniff out cancer from a piece of cloth which had touched the breast of a woman with a tumour, researchers said Friday, announcing the results of an unusual, but promising, diagnostic trial.

'Jumonji' protein key to Ewing's sarcoma rampage

March 24, 2017

By the time Ewing's Sarcoma is diagnosed, primarily in teens and young adults, it has often spread from its primary site to other parts of the body, making it difficult to treat. A University of Colorado Cancer Center study ...

In a sample of blood, researchers probe for cancer clues

March 24, 2017

One day, patients may be able to monitor their body's response to cancer therapy just by having their blood drawn. A new study, led by bioengineers at UC Berkeley, has taken an important step in that direction by measuring ...

Researchers gain insight into breast cancer drug resistance

March 24, 2017

Breast cancer's ability to develop resistance to treatment has frustrated researchers and physicians and has thwarted even the latest and greatest targeted therapies. For example, after researchers identified a disease pathway ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.