Are men with a family history of prostate cancer eligible for active surveillance?

April 6, 2017
Micrograph showing prostatic acinar adenocarcinoma (the most common form of prostate cancer) Credit: Wikipedia

Active surveillance—careful monitoring to determine if or when a cancer warrants treatment—is an increasingly prevalent choice for prostate cancer, but it's unclear if the strategy is appropriate for men with a family history of prostate cancer. A recent analysis of the medical literature concluded that a family history of prostate cancer does not appear to increase a patient's risk of having more aggressive prostate cancer.

In the analysis, six studies found that does not appear to increase the risk of progression, while one study found that family history may increase the risk of only in African Americans.

"Our results suggest that having a family history of prostate cancer should not automatically exclude men from being considered for active surveillance treatments, although some questions remain about risks for African American men with a family history of prostate cancer," said Dr. Jim Dupree, senior author of the BJU International review. "Men obviously need to have thorough conversations with their doctors about risks, benefits, and options, and more research needs to be done to confirm these findings, especially among African American men."

Explore further: New findings concerning hereditary prostate cancer

More information: J.M Telang et al, Prostate cancer, family history, and eligibility for active surveillance: A systematic review of the literature, BJU International (2017). DOI: 10.1111/bju.13862

Related Stories

New findings concerning hereditary prostate cancer

July 11, 2016
It is a well-known fact that men with a family history of prostate cancer run an increased risk of developing the disease. The risk for brothers of men with prostate cancer is doubled. But a doubled risk of what, exactly? ...

Breast cancer risk may be increased in women who have first-degree relatives with a history of prostate cancer

March 9, 2015
Having a family history of prostate cancer among first-degree relatives may increase a woman's risk of developing breast cancer. That is the conclusion of a new study published early online in Cancer, a peer-reviewed journal ...

Prostate cancer tied to higher colorectal cancer risk

March 1, 2016
(HealthDay)—The risk of colorectal cancer is increased after a diagnosis of prostate cancer, according to a study published online Feb. 25 in Cancer.

Prostate cancer mortality benefit seen for family Hx-based screens

January 19, 2015
(HealthDay)—Screening white men with a family history of prostate cancer appears to be associated with a decrease in prostate cancer-specific mortality, according to a study published in the January issue of The Journal ...

Moffitt researchers help lead efforts to find new genetic links to prostate cancer

September 17, 2014
Researchers at Moffitt Cancer Center, including Center Director Thomas A. Sellers, Ph.D., M.P.H., Jong Park, Ph.D. and Hui-Yi Lin, Ph.D., have discovered 23 new regions of the genome that influence the risk for developing ...

Recommended for you

Study provides insight into link between two rare tumor syndromes

August 22, 2017
UCLA researchers have discovered that timing is everything when it comes to preventing a specific gene mutation in mice from developing rare and fast-growing cancerous tumors, which also affects young children. This mutation ...

Retaining one normal BRCA gene in breast, ovarian cancers influences patient survival

August 22, 2017
Determining which cancer patients are likely to be resistant to initial treatment is a major research effort of oncologists and laboratory scientists. Now, ascertaining who might fall into that category may become a little ...

Study identifies miR122 target sites in liver cancer and links a gene to patient survival

August 22, 2017
A new study of a molecule that regulates liver-cell metabolism and suppresses liver-cancer development shows that the molecule interacts with thousands of genes in liver cells, and that when levels of the molecule go down, ...

Zebrafish larvae could be used as 'avatars' to optimize personalized treatment of cancer

August 21, 2017
Portuguese scientists have for the first time shown that the larvae of a tiny fish could one day become the preferred model for predicting, in advance, the response of human malignant tumors to the various therapeutic drugs ...

Scientists discover vitamin C regulates stem cell function, curbs leukemia development

August 21, 2017
Not much is known about stem cell metabolism, but a new study from the Children's Medical Center Research Institute at UT Southwestern (CRI) has found that stem cells take up unusually high levels of vitamin C, which then ...

Searching for the 'signature' causes of BRCAness in breast cancer

August 21, 2017
Breast cancer cells with defects in the DNA damage repair-genes BRCA1 and BRCA2 have a mutational signature (a pattern of base swaps—e.g., Ts for Gs, Cs for As—throughout a genome) known in cancer genomics as "Signature ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.