Sensory motor foot images Credit: Creative Commons / NeuroImage: Clinical

Easing phantom limb pain can be as simple as looking in the mirror.

Scientists who have mapped how mirror changes the brain may now be able to predict just how much treatment will ease a particular patient's pain.

Phantom limb pain—feeling intense pain in a missing limb—happens to more than 90% of amputees and can start just 24 hours after surgery. Drugs don't work well.

Mirror therapy—symmetrical exercises in a mirror where patients "see" their phantom limb move as if it were really there—has long been used to treat it.

Now new research charting brain changes before and after therapy means scientists may soon be able to predict how well it will work in different people.

The sensation-processing part of the brain, the , maps the body surfaces. For example, wiggling your toes activates the 'toe area' of the brain. Losing the limb may alter these maps.

"Mirror therapy works by kind of fooling the brain with visual inputs," said Brunel University London's Dr. Annie Chan. Her study is one of the first to track how over time mirror therapy changes brain activation after the loss of somatosensory feedback from a missing foot through amputation.

Working at the National Institute of Mental Health (Laboratory of Brain and Cognition, Section of learning and Plasticity), Bethesda, U.S., the team measured before, during and after four weeks of daily therapy. They compared results from amputees with those from people without amputations.

"Prior to therapy, we found a strong unexpected activation or response in sensorimotor foot region of amputees to visually presented images of the foot. This unexpected activation was absent in people without amputations," said Dr. Chan.

"This response to visually presented limbs was no longer present at the end of the , when perceived phantom pain was also reduced."

Overall, the amputees' was reduced by 46% from the first scan through to the third session of therapy.

"Our findings highlight the visual responses to the body in amputees might be useful in predicting efficacy of pain management programme for other neuropathy pain. Future work will be needed to establish the robustness of our findings with a much larger sample size and whether similar effects are observed in arm amputees. "

More information: Annie W.-Y. Chan et al. Visual responsiveness in sensorimotor cortex is increased following amputation and reduced after mirror therapy, NeuroImage: Clinical (2019). DOI: 10.1016/j.nicl.2019.101882

Journal information: NeuroImage: Clinical

Provided by Brunel University