Study of early onset menopausal symptoms could predict heart disease

Women who experience hot flashes and night sweats earlier in life are more likely to die from cardiovascular disease (CVD) when compared to women with later onset menopausal symptoms, according to research from the University of Pittsburgh School of Medicine published today in the journal, Menopause.

Up to 80 percent of women experience menopausal symptoms, particularly hot flashes and night sweats, at some point during the menopause transition, said Rebecca Thurston, Ph.D., professor of psychiatry, Pitt School of Medicine.

"We used to think these were annoying symptoms that persist for several years around the final menstrual period and simply affect the quality of life for many women," she said. "However, we now know that these symptoms persist far longer and often start earlier than we previously thought. Our research also suggests that for some women, particularly for younger midlife women, menopausal symptoms might mark adverse changes in the blood vessels during midlife that place them at increased risk for heart disease."

The research indicates that early onset of menopausal symptoms is associated with dysfunction of the endothelium, which is the lining of blood vessels. Endothelial dysfunction was measured by assessing flow-mediated dilation (FMD), a noninvasive ultrasound measure of how well the vessel dilates in response to pressure on the wall of the blood vessel.

Dr. Thurston and her colleagues investigated associations between and risk for CVD complications among participating in the National Heart, Lung, and Blood Institute Women's Ischemia Syndrome Evaluation study. A total of 254 postmenopausal women with signs and symptoms of ischemic heart disease were evaluated, and researchers found those who had before age 42 to be more likely to have lower FMD, suggesting adverse endothelial changes, as well as higher mortality from .

"While more work needs to be done to confirm our findings, our research could, one day, help us predict the midlife women who might be at increased risk for so that we proactively target these for early prevention strategies," Dr. Thurston said.

Explore further

Hot flashes at younger age may signal greater cardiovascular risk

More information: Rebecca C. Thurston et al. Menopausal symptoms and cardiovascular disease mortality in the Women╩╝s Ischemia Syndrome Evaluation (WISE), Menopause (2016). DOI: 10.1097/GME.0000000000000731
Journal information: Menopause

Citation: Study of early onset menopausal symptoms could predict heart disease (2016, September 28) retrieved 24 October 2020 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Feedback to editors

User comments