How animals 'dial up' the pain they experience from certain stimuli

back pain
Credit: CC0 Public Domain

Scientists have—for the first time—shown how chemical triggers in the nervous system can amplify the pain experienced by mammals in response to certain stimuli.

The system probably evolved to alert them to life-threatening dangers. As they approach objects that are extremely hot or cold or are biting them, they experience intense pain—allowing them to get out of harm's way.

But in certain diseases, that defence mechanism malfunctions and rather than providing a short, sharp shock—it produces long-term, , seen with some conditions affecting humans such as neuropathies, arthritic pains or migraines.

Researchers at the University of Leeds, in collaboration with colleagues in the US and China, have discovered that, under certain conditions, the molecular sensors that make nerves respond to physical stimuli can be turbo charged—to intensify the reaching the brain. The brain interprets those signals as pain.

In animal studies using rat nerve cells, they found that the normal chemical messaging system utilized by the nerves to detect heat and involving calcium ions as 'messengers' was supplemented by what is known as the calcium-activated chlorine channel. It is this combination that amplifies the electrical signal to the brain.

Their research findings are published today in the journal Science Signaling.

The research team used a technique called super-resolution microscopy which allowed them to see in exceptional detail the interaction of the molecules involved in nerve signalling.

Nikita Gamper, Professor of Neuroscience in the Faculty of Biological Sciences at Leeds, supervised the research. He said: "Our findings show how environmental threats are detected and then processed by the nervous system.

"And of course, this understanding is also important for us to be able to combat the flip side of the pain sensation—when people begin to experience pain that is no longer protective or beneficial, such as pain from inflammation, cancer and many other conditions.

"These are conditions that damage the quality of life experience by many people."

This pain amplification mechanism happens in the which feeds into—but is separate from—the central nervous system, made up of the spinal column and brain. For Professor Gamper, that division opens-up the possibility that drug therapies to reduce chronic pain could be targeted on the peripheral nervous system rather than the brain.

He said: "The painkillers that we currently use act on the central nervous system and brain. Developing painkillers that work on brain function is very hard because the brain is a complex organ and although you might solve one problem, you often get unwanted side effects.

"Opioids are standard analgesics, but they are highly addictive. Therapies based on the peripheral nervous system would potentially have less effect on the ."

Although the study was conducted on cells from rats and the applicability to the human is yet to be confirmed, there are reasons to believe that while there is a big difference between the human and rat brains, the peripheral nervous systems bear much closer similarity.

More information: "Local Ca2+ signals couple activation of TRPV1 and ANO1 sensory ion channels," Science Signaling (2020). … 26/scisignal.aaw7963

Journal information: Science Signaling

Citation: How animals 'dial up' the pain they experience from certain stimuli (2020, April 28) retrieved 27 March 2023 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

'Pain paradox' discovery provides route to new pain control drugs


Feedback to editors