Sweat glands play major role in healing human wounds, research shows

Credit: University of Michigan Health System

Turns out the same glands that make you sweat are responsible for another job vital to your health: they help heal wounds.

Human skin is rich with millions of eccrine sweat glands that help your body cool down after a trip to the gym or on a warm day. These same glands, new University of Michigan Health System research shows, also happen to play a key role in providing cells for recovering – such as scrapes, burns and ulcers.

The findings were released online ahead of print in the .

" – including those caused by diabetes or bed sores – and other non- remain a tremendous burden on health services and communities around the world," says lead author Laure Rittié, Ph.D., research assistant professor of dermatology at the University of Michigan Medical School.

"Treating chronic wounds costs tens of billions of dollars annually in the United States alone, and this price tag just keeps rising. Something isn't working."

Now, U-M researchers believe they have discovered one of the body's most powerful secret weapons in healing.

"By identifying a key process of wound closure, we can examine drug therapies with a new target in mind: sweat glands, which are very under-studied," Rittié says. "We're hoping this will stimulate research in a promising, new direction."

Previous understanding of was that new skin cells originate from hair follicles and from intact skin at the edge of the wound. The U-M findings demonstrate that cells arise from beneath the wound, and suggest that human eccrine sweat glands also store an important reservoir of that can quickly be recruited to aid wound healing.

"It may be surprising that it's taken until now to discover the sweat glands' vital role in wound repair," Rittié says. "But there's a good reason why these specific glands are under-studied – eccrine sweat glands are unique to humans and absent in the body skin of laboratory animals that are commonly used for wound healing research.

"We have discovered that humans heal their skin in a very unique way, different from other mammals," Rittié adds. "The regenerative potential of sweat glands has been one of our body's best-kept secrets. Our findings certainly advance our understanding of the normal healing process and will hopefully pave the way for designing better, targeted therapies."

More information: dx.doi.org/10.1016/j.ajpath.2012.09.019

Related Stories

Artificial skin system can heal wounds

Dec 20, 2007

A new study in Artificial Organs tested the effects of a wound dressing created with hair follicular cells. The findings reveal that skin substitutes using living hair cells can increase wound healing.

Study uses bone marrow stem cells to regenerate skin

Jan 14, 2009

A new study suggests that adult bone marrow stem cells can be used in the construction of artificial skin. The findings mark an advancement in wound healing and may be used to pioneer a method of organ reconstruction. The ...

Recommended for you

Better living through mitochondrial derived vesicles

17 hours ago

(Medical Xpress)—As principal transformers of bacteria, organelles, synapses, and cells, vesicles might be said to be the stuff of life. One need look no further than the rapid rise to prominence of The ...

Zebrafish help to unravel Alzheimer's disease

18 hours ago

New fundamental knowledge about the regulation of stem cells in the nerve tissue of zebrafish embryos results in surprising insights into neurodegenerative disease processes in the human brain. A new study by scientists at ...

Engineering new bone growth

20 hours ago

MIT chemical engineers have devised a new implantable tissue scaffold coated with bone growth factors that are released slowly over a few weeks. When applied to bone injuries or defects, this coated scaffold ...

User comments