Tumor blood vessel protein provides potential therapeutic target

August 27, 2014, Journal of Clinical Investigation

Tumor blood vessels supply oxygen and nutrients to cancer cells and provide access to other organs. While tumor vasculature shares many features with normal vessels, their unique characteristics are potential therapeutic targets.

A recent study in the Journal of Clinical Investigation identifies a tumor vessel-specific protein, L1 that can be targeted to reduce .

Using a mouse pancreatic cancer model, Ugo Cavallaro and colleagues at the European Institute of Oncology found that loss of L1 reduced tumor blood vessel formation, which inhibited growth and metastasis. In patients with pancreatic cancer, L1 was present within and not in vessels of healthy tissue.

The results from this study suggest that targeting L1 has potential as a cancer-limiting strategy.

Explore further: Starving pancreatic cancer before it has a chance to feast

More information: Endothelial deficiency of the adhesion molecule L1 reduces tumor angiogenesis and promotes vessel normalization, J Clin Invest. DOI: 10.1172/JCI70683

Related Stories

Starving pancreatic cancer before it has a chance to feast

June 23, 2014
(Medical Xpress)—Pancreatic cancer's low survival rate gives researchers from The University of Kansas Cancer Center even more reason to find a way to prevent and treat the hard-to-detect cancer. Drs. Snigdha Banerjee, ...

Malaria medicine chloroquine inhibits tumor growth and metastases

August 11, 2014
A recent study by investigators at VIB and KU Leuven has demonstrated that chloroquine also normalizes the abnormal blood vessels in tumors. This blood vessel normalization results in an increased barrier function on the ...

Researchers identify targets for immunotherapy in early-stage breast cancer

July 18, 2014
Yale Cancer Center researchers used a new molecular analysis tool to accurately detect the level of an important target for immunotherapy in early-stage breast cancers. The diagnostic test, using RNAScope, measures the amount ...

Labeling technique during noninvasive tumor imaging could predict response to chemotherapy

July 16, 2014
Being able to view tumor blood vessels without surgery or potent dyes can improve our understanding of the environment in which a tumor grows. Now, a team of researchers, including Chang-Tong Yang from the A*STAR Singapore ...

Biomarker identifies melanoma patients who may respond to immunotherapy MK-3475

April 7, 2014
Among melanoma patients treated with the PD-1 inhibitor MK-3475, those whose tumors had the protein PD-L1 had better immune responses and higher survival rates, according to results presented here at the AACR Annual Meeting ...

Researchers generate immunity against tumor vessel protein

April 25, 2014
Sometimes a full-on assault isn't the best approach when dealing with a powerful enemy. A more effective approach, in the long run, may be to target the support system replenishing the supplies that keep your foe strong and ...

Recommended for you

Implantable islet cells come with their own oxygen supply

April 25, 2018
Since the 1960s, researchers have been interested in the possibility of treating type 1 diabetes by transplanting islet cells—the pancreatic cells that are responsible for producing insulin when blood glucose concentration ...

'Incompatible' donor stem cells cure adult sickle cell patients

April 25, 2018
Doctors at the University of Illinois Hospital have cured seven adult patients of sickle cell disease, an inherited blood disorder primarily affecting the black community, using stem cells from donors previously thought to ...

Research explains link between exercise and appetite loss

April 24, 2018
Ever wonder why intense exercise temporarily curbs your appetite? In research described in today's issue of PLOS Biology, Albert Einstein College of Medicine researchers reveal that the answer is all in your head—more specifically, ...

Mammary stem cells challenge costly bovine disease

April 24, 2018
Mastitis is the most expensive disease in the dairy industry. Each clinical case can cost a dairy farmer more than $400 and damages both the cow's future output as well as her comfort.

Fruit fly study identifies new gene linked to aortic aneurysms

April 24, 2018
An interdisciplinary team of researchers has identified a new gene linked to human aortic aneurysms. By combining comprehensive genetic studies in the fruit fly, dataset searches and analysis of diseased human aortic tissue, ...

Scientists manipulate 'satellite cells' to speed healing

April 24, 2018
Muscle aches and pains, whether from stretching, strenuous exercise or just normal wear and tear, can put a crimp in your day, a limp in your step and be an actual pain in the neck. But no matter the severity, stem cells ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.