Oncology & Cancer

A potential new cancer target

The role of transforming growth factor beta (TGF-beta) in cancer progression is still not fully understood due its context-dependent biology.

Medical research

'Terminator' protein halts cancer-causing cellular processes

Essential processes in mammalian cells are controlled by proteins called transcription factors. For example, the transcription factor HIF-1 is triggered by a low-oxygen situation to cause the cell to adapt to decreased oxygen.

Oncology & Cancer

Notorious cancer protein mutations cooperate to proliferate disease

Understanding the genetic mutations and protein changes that take place in the progression of cancer is key to its treatment. Mutations in the gene TP53 and concomitant mutant p53 proteins in cancer cells have become notorious ...

Oncology & Cancer

Researchers study radiation resistance in brain cancer cells

In a vertical climb to avoid collision with a towering mountain, a plane ejects cargo to gain altitude. Investigators at the University of Minnesota showed that cancer cells perform similar feats in escaping the killing effects ...

Medical research

The role of miRNAs in glioblastoma multiforme

Glioblastoma multiforme is one of the most malignant tumors of the central nervous system. It is characterized by the fast growth and high malignancy. Although surgery combined with radiation therapy and chemotherapy has ...

Oncology & Cancer

New targets for childhood brain tumors identified

People with the genetic condition neurofibromatosis type 1 (NF1) are prone to developing tumors on nervous system tissue. A new study from Washington University School of Medicine in St. Louis has found that the development ...

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Transforming growth factor

Transforming growth factor (sometimes referred to as Tumor growth factor, or TGF) is used to describe two classes of polypeptide growth factors, TGFα and TGFβ.

The name "Transforming Growth Factor" is somewhat arbitrary, since the two classes of TGFs are not structurally or genetically related to one another, and they act through different receptor mechanisms. Furthermore, they do not always induce cellular transformation, and are not the only growth factors that induce cellular transformation.

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