Oncology & Cancer

Tissue physics plays a key role in tumor growth

Cancer is a difficult disease to treat and to study, and can be caused by a range of genetic mutations. For instance, the mutated RAS gene causes a loss of structure in so-called epithelial tissue, a tissue type that lines ...

Oncology & Cancer

Metastases use divided blood vessels to grow

For the first time, researchers at the University of Gothenburg have shown that metastases in patients with malignant melanoma gain access to the circulatory system not only through the outgrowth of new blood vessel branches, ...

Oncology & Cancer

Cascade-responsive nanobomb for anti-tumor synergistic therapies

Reactive oxygen species (ROS) can act as signal carriers during the evolution of malignant tumors. At the appropriate concentration, ROS mediate signal transduction and cell growth. However, ROS are a double-edged sword, ...

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Transforming growth factor

Transforming growth factor (sometimes referred to as Tumor growth factor, or TGF) is used to describe two classes of polypeptide growth factors, TGFα and TGFβ.

The name "Transforming Growth Factor" is somewhat arbitrary, since the two classes of TGFs are not structurally or genetically related to one another, and they act through different receptor mechanisms. Furthermore, they do not always induce cellular transformation, and are not the only growth factors that induce cellular transformation.

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