For patients with acute lymphoblastic leukemia (ALL) carrying the Philadelphia chromosome and whose disease relapsed after allogeneic hematopoietic stem cell transplantation (HCT), the two-year overall survival rate has nearly ...
Jan 12, 2022
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A molecular building block of many animal proteins, the amino acid valine, plays a key role in cancerous growth seen in T cell acute lymphoblastic leukemia, a new study shows.
Dec 22, 2021
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A new study published now in Nature Communications, led by João T. Barata from Instituto de Medicina Molecular João Lobo Antunes (iMM, Portugal), and J. Andrés Yunes from Centro Infantil Boldrini (Brazil), shows that changes ...
Dec 14, 2021
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The combination of dasatinib, blinatumomab, and prednisone can be effective in treating older patients with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) who are not good candidates for intensive ...
Dec 13, 2021
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Acute lymphoblastic leukemia (ALL), a cancer involving white blood cells known as lymphocytes, is the most common childhood cancer, representing 25% of all cancer diagnoses. It's also one of the leading causes of childhood ...
Sep 10, 2021
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New research published today in JAMA Oncology reports how two separate DNA changes appear to predict aggressive childhood leukemias when they occur in combination. Over the course of a decade of work in several study sites ...
Aug 20, 2021
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A one-two punch envisioned by many as a way to improve treatment for some blood cancers may be more challenging to implement than previously expected, according to researchers at Stanford Medicine.
Aug 4, 2021
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Scientists at St. Jude Children's Research Hospital are working with colleagues in China to develop better therapy for childhood acute lymphoblastic leukemia (ALL). Results from a large phase 3 noninferiority clinical trial ...
Jul 28, 2021
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St. Jude Children's Research Hospital investigators have demonstrated that comprehensive genomic sequencing of all pediatric cancer patients is feasible and essential to capitalize on the lifesaving potential of precision ...
Jul 23, 2021
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A team of researchers affiliated with multiple institutions in Germany and France has found that a subgroup of T-cell acute lymphoblastic leukemia (T-ALL) mouse models benefited from a targeted therapy. In their paper published ...
