Chronic Lymphocytic Leukemia

Gene therapy scores big wins against blood cancers

In one of the biggest advances against leukemia and other blood cancers in many years, doctors are reporting unprecedented success by using gene therapy to transform patients' blood cells into soldiers that ...

Dec 07, 2013
popularity 4.8 / 5 (32) | comments 2

Monoclonal antibody targets, kills leukemia cells

Researchers at the University of California, San Diego Moores Cancer Center have identified a humanized monoclonal antibody that targets and directly kills chronic lymphocytic leukemia (CLL) cells.

Mar 25, 2013
popularity 5 / 5 (5) | comments 0 | with audio podcast

Gene in eye melanomas linked to good prognosis

Melanomas that develop in the eye often are fatal. Now, scientists at Washington University School of Medicine in St. Louis report they have identified a mutated gene in melanoma tumors of the eye that appears ...

Jan 16, 2013
popularity not rated yet | comments 0 | with audio podcast

Tumor cells' inner workings predict cancer progression

Using a new assay method to study tumor cells, researchers at the University of California, San Diego School of Medicine and UC San Diego Moores Cancer Center have found evidence of clonal evolution in chronic ...

Jul 27, 2012
popularity 5 / 5 (1) | comments 0 | with audio podcast

Modified killer T-cells wipe out leukemia: study

Three US cancer patients were brought back from the brink by a new therapy that turned their own immune cells into tumor killers, wiping out an advanced form of leukemia, researchers said Wednesday.

Aug 10, 2011
popularity 5 / 5 (18) | comments 3

Researchers explore function of cancer-causing gene

Developmental biologists at the University of Georgia are discovering new roles for a specific gene known as Max's Giant Associated protein, or MGA. A little studied protein, MGA appears to control a number of developmental ...

Mar 26, 2014
popularity 5 / 5 (1) | comments 0

Chemo-free treatment a possibility for leukemia / lymphoma

Patients with terminal forms of leukaemia and lymphoma who have run out of treatment options could soon benefit from a new drug, which not only puts an end to chemotherapy and has virtually no side effects but also improves ...

Mar 19, 2014
popularity 5 / 5 (2) | comments 0

East Asian genes may solve the skin cancer puzzle

Europeans fall prey to skin cancer because of their lighter skin, while Africans' dark skin protects them. But East Asians, whose skin colour resembles that of Europeans, are similar to Africans in their ...

Jan 07, 2014
popularity 5 / 5 (2) | comments 0

B-cell chronic lymphocytic leukemia (B-CLL), also known as chronic lymphoid leukemia (CLL), is the most common type of leukemia. Leukemias are cancers of the white blood cells (leukocytes). CLL affects B cell lymphocytes. B cells originate in the bone marrow, develop in the lymph nodes, and normally fight infection by producing antibodies. In CLL, the DNA of a B cell is damaged, so that it cannot produce antibodies.[citation needed] Additionally, B cells grow out of control and accumulate in the bone marrow and blood, where they crowd out healthy blood cells. CLL is a stage of small lymphocytic lymphoma (SLL), a type of B-cell lymphoma, which presents primarily in the lymph nodes. CLL and SLL are considered the same underlying disease, just with different appearances.

CLL is a disease of adults, but, in rare cases, it can occur in teenagers and occasionally in children (inherited). Most (>75%) people newly diagnosed with CLL are over the age of 50, and the majority are men.

Most people are diagnosed without symptoms as the result of a routine blood test that returns a high white blood cell count, but, as it advances, CLL results in swollen lymph nodes, spleen, and liver, and eventually anemia and infections. Early CLL is not treated, and late CLL is treated with chemotherapy and monoclonal antibodies.

DNA analysis has distinguished two major types of CLL, with different survival times. CLL that is positive for the marker ZAP-70 has an average survival of 5 years. CLL that is negative for ZAP-70 has an average survival of more than 25 years. Many patients, especially older ones, with slowly progressing disease can be reassured and may not need any treatment in their lifetimes.

This text uses material from Wikipedia licensed under CC BY-SA

Latest Spotlight News

Man among first in US to get 'bionic eye' (Update)

A degenerative eye disease slowly robbed Roger Pontz of his vision. Diagnosed with retinitis pigmentosa as a teenager, Pontz has been almost completely blind for years. Now, thanks to a high-tech procedure ...

Classifying sequence variants in human disease

Sequencing an entire human genome is faster and cheaper than ever before, leading to an explosion of studies comparing the genomes of people with and without a given disease. Often clinicians and researchers studying genetic ...

Deliberation is staunchest ally of selfishness

(Medical Xpress)—Over the last two years, Yale psychologist David Rand and colleagues have investigated what makes people willing to help each other. Their latest research shows that while initial reactions ...