Large-scale genetic study defines relationship between primary sclerosing cholangitis and other autoimmune diseases
For the first time, scientists show that a leading cause of liver transplant, primary sclerosing cholangitis (PSC), is a distinct disease from inflammatory bowel disease, opening up new avenues for specific PSC treatments.
Genetics Apr 21, 2013 | not rated yet | 0 |
A University of Colorado Boulder-led team has discovered two prime targets of the Hepatitis B virus in liver cells, findings that could lead to treatment of liver disease in some of the 400 million people worldwide currently ...
Diseases, Conditions, Syndromes Oct 22, 2012 | 3.7 / 5 (3) | 0 |
(Medical Xpress) -- A new vaccine against the chronic liver disease hepatitis C has shown promising results in a first clinical trial in humans, Oxford University researchers report.
Diseases, Conditions, Syndromes Jan 05, 2012 | 5 / 5 (4) | 0 |
Researchers have identified a large number of areas in the human genetic code that are involved in regulating the way in which the liver functions, in a new study of over 61,000 people, published today in the journal Nature Ge ...
Genetics Oct 16, 2011 | 5 / 5 (2) | 0 |
For the first time, scientists have cleanly corrected a human gene mutation in a patient's stem cells. The result, reported in Nature on Wednesday 12 October, brings the possibility of patient-specific therapies closer to bec ...
Genetics Oct 12, 2011 | 4.6 / 5 (10) | 0 |
Johns Hopkins researchers have demonstrated that human liver cells derived from adult cells coaxed into an embryonic state can engraft and begin regenerating liver tissue in mice with chronic liver damage.
Medical research May 11, 2011 | 4.3 / 5 (6) | 2 |
Regular consumption of coffee is associated with a reduced risk of primary sclerosing cholangitis (PSC), an autoimmune liver disease, Mayo Clinic research shows. The findings were being presented at the Digestive Disease ...
Diseases, Conditions, Syndromes May 19, 2013 | not rated yet | 0 |
Liver fibrosis results from an excessive accumulation of tough, fibrous scar tissue and occurs in most types of chronic liver diseases. In industrialized countries, the main causes of liver injury leading ...
Medical research Apr 25, 2013 | 5 / 5 (1) | 0 |
New discoveries by a team of scientists at LSU Health Sciences Center New Orleans for the first time reveal the inner workings of a master regulator that controls functions as diverse as the ability of nerve cells to "rewire" ...
Medical research Apr 10, 2013 | 5 / 5 (1) | 0 |
(HealthDay)—An experimental therapy for hepatitis C—a "silent killer" linked to liver cancer and cirrhosis—has shown promise in tamping down virus levels in early trials.
Diseases, Conditions, Syndromes Mar 27, 2013 | 5 / 5 (3) | 1 |
For decades scientists around the world have attempted to regenerate primary liver cells known as hepatocytes because of their numerous biomedical applications, including hepatitis research, drug metabolism and toxicity studies, ...
Medical research Feb 25, 2013 | 5 / 5 (5) | 0 |
A study by researchers from Los Alamos National Laboratory and a multinational team reveals how daclatasvir, a direct-acting antiviral agent in development for the treatment of hepatitis C virus (HCV), targets one of its ...
Diseases, Conditions, Syndromes Feb 18, 2013 | 4.8 / 5 (4) | 0 |
(Medical Xpress)—Research at Oregon State University has found that one particular omega-3 fatty acid has a powerful effect in preventing liver inflammation and fibrosis – common problems that are steadily rising along ...
Diseases, Conditions, Syndromes Feb 05, 2013 | not rated yet | 0 |
A team of scientists has developed a playbook for ending the devastating impact of fibrotic diseases of the liver, lung, kidney, and other organs, which are responsible for as many as 45 percent of all deaths in the industrialized ...
Medical research Jan 09, 2013 | not rated yet | 0 |
(Medical Xpress)—Scientists have discovered a gene that interferes with the clearance of hepatitis C virus infection. They also identified an inherited variant within this gene, Interferon Lambda 4 (IFNL4), that predicts ...
Genetics Jan 08, 2013 | 5 / 5 (1) | 0 |
Cirrhosis ( /sɪˈroʊsɪs/) is a consequence of chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue and regenerative nodules (lumps that occur as a result of a process in which damaged tissue is regenerated), leading to loss of liver function. Cirrhosis is most commonly caused by alcoholism, hepatitis B and C, and fatty liver disease, but has many other possible causes. Some cases are idiopathic, i.e., of unknown cause.
Ascites (fluid retention in the abdominal cavity) is the most common complication of cirrhosis, and is associated with a poor quality of life, increased risk of infection, and a poor long-term outcome. Other potentially life-threatening complications are hepatic encephalopathy (confusion and coma) and bleeding from esophageal varices. Cirrhosis is generally irreversible, and treatment usually focuses on preventing progression and complications. In advanced stages of cirrhosis the only option is a liver transplant.
The word "cirrhosis" derives from Greek κιρρός [kirrhós] meaning yellowish, tawny (the orange-yellow colour of the diseased liver) + Eng. med. suff. -osis. While the clinical entity was known before, it was René Laennec who gave it the name "cirrhosis" in his 1819 work in which he also describes the stethoscope.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
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