Cushing Disease

Plant extract fights brain tumour

Silibinin has an outstanding safety profile in humans and is currently used for the treatment of liver disease and poisoning. Scientists at the Max Planck Institute of Psychiatry in Munich discovered in collaboration ...

Feb 10, 2015
popularity 4358 comments 1

Cushing's syndrome is a hormone disorder caused by high levels of cortisol in the blood. This can be caused by taking glucocorticoid drugs, or by tumors that produce cortisol or adrenocorticotropic hormone (ACTH) or CRH.

Cushing's disease refers to one specific cause of the syndrome: a tumor (adenoma) in the pituitary gland that produces large amounts of ACTH, which in turn elevates cortisol. It is the most common cause of Cushing's syndrome, responsible for 70% of cases excluding glucocorticoid related cases.

This pathology was described by Harvey Cushing in 1932. The syndrome is also called Itsenko-Cushing syndrome, hyperadrenocorticism or hypercorticism.

Cushing's syndrome is not confined to humans and is also a relatively common condition in domestic dogs and horses. It also occurs in cats, but rarely.

It should not be confused with Cushing's triad, a disease state resulting from increased intracranial pressure.

This text uses material from Wikipedia licensed under CC BY-SA

Latest Spotlight News

Mathematical model seeks functional cure for HIV

(Medical Xpress)—Individuals with the natural ability to control HIV infection in the absence of treatment are referred to as elite controllers (ECs). Such individuals maintain undetectable viral loads ...

Neurons constantly rewrite their DNA

Johns Hopkins scientists have discovered that neurons are risk takers: They use minor "DNA surgeries" to toggle their activity levels all day, every day. Since these activity levels are important in learning, ...

Finding the body clock's molecular reset button

An international team of scientists has discovered what amounts to a molecular reset button for our internal body clock. Their findings reveal a potential target to treat a range of disorders, from sleep ...

Researchers bring order to big data of human biology

A multi-year study led by researchers from the Simons Center for Data Analysis (SCDA) and major universities and medical schools has broken substantial new ground, establishing how genes work together within ...