Systemic Lupus Erythematosus

Dry mouth can reveal lingering health issues

Deborah Berry had visited numerous health-care professionals, but no one was able to accurately diagnose and treat the many lumps and cuts on the inside of her mouth. Berry, who suffers from systemic lupus erythematosus, ...

May 06, 2015
popularity12 comments 0

Systemic lupus erythematosus (i/sɨˈstɛmɪk ˈluːpəs ˌɛrɨθiːməˈtoʊsəs/), often abbreviated to SLE or lupus, is a systemic autoimmune disease (or autoimmune connective tissue disease) that can affect any part of the body. As occurs in other autoimmune diseases, the immune system attacks the body's cells and tissue, resulting in inflammation and tissue damage. It is a Type III hypersensitivity reaction caused by antibody-immune complex formation.

SLE most often harms the heart, joints, skin, lungs, blood vessels, liver, kidneys, and nervous system. The course of the disease is unpredictable, with periods of illness (called flares) alternating with remissions. The disease occurs nine times more often in women than in men, especially in women in child-bearing years ages 15 to 35, and is also more common in those of non-European descent.

SLE is treatable using immunosuppression, mainly with cyclophosphamide, corticosteroids and other immunosuppressants; there is currently no cure. SLE can be fatal, although with recent medical advances, fatalities are becoming increasingly rare. Survival for people with SLE in the United States, Canada, and Europe has risen to approximately 95% at five years, 90% at 10 years, and 78% at 20 years, and now approaches that of matched controls without lupus.

Childhood systemic lupus erythematosus generally presents between the ages of 3 and 15, with girls outnumbering boys 4:1, and typical skin manifestations being butterfly eruption on the face and photosensitivity.

This text uses material from Wikipedia licensed under CC BY-SA

Latest Spotlight News

Repeating aloud to another person boosts recall

Repeating aloud boosts verbal memory, especially when you do it while addressing another person, says Professor Victor Boucher of the University of Montreal's Department of Linguistics and Translation. His findings are the ...

How the brain's wiring leads to cognitive control

How does the brain determine which direction to let its thoughts fly? Looking for the mechanisms behind cognitive control of thought, researchers at the University of Pennsylvania, University of California and United States ...

Runner's high linked to cannabinoid receptors in mice

(Medical Xpress)—A team of researchers from several institutions in Germany has found a link between cannabinoid receptors in mice and what is commonly known as "runner's high." In their paper published in Proceedings of ...

What role does the hippocampus play in memory?

(Medical Xpress)—Meet the hippocampus: A seahorse-shaped structure in the cerebral cortex's medial temporal lobe, it's part of the limbic system, generally believed to be involved in spatial navigation and establishing ...

Snapshot turns T cell immunology on its head

Challenging a universally accepted, longstanding consensus in the field of immunity requires hard evidence. New research from the Australian Research Council Centre of excellence in advanced Molecular imaging has shown the ...