Systemic Lupus Erythematosus
Lupus ups risk of spontaneous subarachnoid hemorrhage
(HealthDay)—Patients with systemic lupus erythematosus (SLE) have an increased risk of spontaneous subarachnoid hemorrhage (SAH) and increased mortality after SAH, according to a study published in the ...
Arthritis & Rheumatism
Apr 19, 2013 |
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Protein implicated in lupus promotes disease progression by distinct mechanisms in different immune cells
Patients with systemic lupus erythematosus (SLE) come under attack by their immune system, producing 'autoantibodies' that inflict damage throughout the body. Antibodies normally target foreign proteins, ...
Immunology
Mar 13, 2013 |
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A nanogel-based treatment for lupus
Systemic lupus erythematosus (SLE) is disease in which the immune system mistakenly attacks healthy tissues, resulting in inflammation and tissue damage. Current treatments are focused on suppression of the immune system, ...
Diseases, Conditions, Syndromes
Mar 01, 2013 |
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Scientists find key element of lupus, suggesting better drug targets
A team led by scientists at The Scripps Research Institute (TSRI) has identified specific cellular events that appear key to lupus, a debilitating autoimmune disease that afflicts tens of millions of people worldwide. The ...
Medical research
Feb 04, 2013 |
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Lupus: Peptide P140/LupuzorTM effectiveness confirmed
A clinical trial with 149 patients suffering from the very disabling autoimmune disease systemic lupus erythematosus, has shown the effectiveness of a synthetic peptide developed by a team of researchers led by CNRS biologist ...
Arthritis & Rheumatism
Jan 25, 2013 |
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Research: Lupus drugs carry no significant cancer risk for patients
People who take immunosuppressive drugs to treat lupus do not necessarily increase their cancer risk according to new research led by scientists at the Research Institute of the McGill University Health Centre (RI-MUHC). ...
Medications
Jan 24, 2013 |
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Canadian pediatric lupus severity varies with ethnicity
(HealthDay)—While Canadian children with systemic lupus erythematosus (SLE) differ in disease characteristics and severity by ethnicity, treatment, disease activity, and irreversible organ damage are similar ...
Arthritis & Rheumatism
Jan 22, 2013 |
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Teen vitamin D intake not related to adult RA or SLE risk
(HealthDay)—Dietary vitamin D intake during adolescence does not appear to be associated with the risk of adult-onset rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE), according to research ...
Arthritis & Rheumatism
Dec 28, 2012 |
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Predictors of organ damage identified in patients with SLE
(HealthDay)—Patient age, hypertension, and corticosteroid use are the most important predictors of the cumulative organ damage that occurs in patients with systemic lupus erythematosus (SLE), according ...
Arthritis & Rheumatism
Dec 16, 2012 |
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Indigenous Australians vulnerable to lupus
(Medical Xpress)—A new study is currently exploring why Indigenous Australians (IA) suffer more frequently and severely from lupus than non-Indigenous Australians (NIA).
Diseases, Conditions, Syndromes
Dec 14, 2012 |
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Lenalidomide offers an effective alternative treatment for cutaneus lupus erythematosus
Although rare there are several treatments available for cutaneus lupus erythematosus (CLE). However other options are needed for people who do not respond to medication or relapse. A new study into the thalidomide derivative ...
Cancer
Dec 07, 2012 |
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Uranium exposure linked to high lupus rates in community living near a former refinery
High rates of systemic lupus erythematosus have been linked to living in proximity to a former uranium ore processing facility in Ohio, according to new research findings presented this week at the American College of Rheumatology ...
Diseases, Conditions, Syndromes
Nov 13, 2012 |
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Statins have potential to treat an autoimmune clotting disorder called antiphospholipid syndrome
New research suggests that statins, traditionally used for cholesterol lowering, could be used in the management of individuals who are at risk for developing clotting because they have autoimmune antiphospholipid antibodies ...
Immunology
Nov 11, 2012 |
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Antirheumatic drugs have minor effect on preeclampsia risk
(HealthDay)—The use of a disease-modifying antirheumatic drug (DMARD) during pregnancy is rare and is associated with a nonsignificant increase in the risk for preeclampsia in women with autoimmune disease, ...
Diseases, Conditions, Syndromes
Nov 06, 2012 |
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Women with lupus have a higher risk for preeclampsia
New research reports that women with systemic lupus erythematosus (SLE) have a two-fold increase in risk of preeclampsia—a dangerous condition in which pregnant women develop high blood pressure (hypertension) and protein ...
Diseases, Conditions, Syndromes
Oct 30, 2012 |
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Systemic lupus erythematosus (i/sɨˈstɛmɪk ˈluːpəs ˌɛrɨθiːməˈtoʊsəs/), often abbreviated to SLE or lupus, is a systemic autoimmune disease (or autoimmune connective tissue disease) that can affect any part of the body. As occurs in other autoimmune diseases, the immune system attacks the body's cells and tissue, resulting in inflammation and tissue damage. It is a Type III hypersensitivity reaction caused by antibody-immune complex formation.
SLE most often harms the heart, joints, skin, lungs, blood vessels, liver, kidneys, and nervous system. The course of the disease is unpredictable, with periods of illness (called flares) alternating with remissions. The disease occurs nine times more often in women than in men, especially in women in child-bearing years ages 15 to 35, and is also more common in those of non-European descent.
SLE is treatable using immunosuppression, mainly with cyclophosphamide, corticosteroids and other immunosuppressants; there is currently no cure. SLE can be fatal, although with recent medical advances, fatalities are becoming increasingly rare. Survival for people with SLE in the United States, Canada, and Europe has risen to approximately 95% at five years, 90% at 10 years, and 78% at 20 years, and now approaches that of matched controls without lupus.
Childhood systemic lupus erythematosus generally presents between the ages of 3 and 15, with girls outnumbering boys 4:1, and typical skin manifestations being butterfly eruption on the face and photosensitivity.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
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