Type 1 Diabetes
Mapping genes: Study finds new risk factors for neurodegenerative diseases
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Preventing diabetes: Researchers measure loss of human pancreas cells
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First blood test to diagnose major depression in teens
A Northwestern Medicine scientist has developed the first blood test to diagnose major depression in teens, a breakthrough approach that allows an objective diagnosis by measuring a specific set of genetic markers found in ...
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Apr 17, 2012 |
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Researchers search public databases, flag novel gene's key role in type 2 diabetes
Using computational methods, Stanford University School of Medicine investigators have strongly implicated a novel gene in the triggering of type-2 diabetes. Their experiments in lab mice and in human blood and tissue samples ...
Genetics
Apr 09, 2012 |
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Whole genome sequencing not informative for all, study shows
With sharp declines in the cost of whole genome sequencing, the day of accurately deciphering disease risk based on an individual's genome may seem at hand. But a study involving data of thousands of identical twins by Johns ...
Genetics
Apr 02, 2012 |
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Rare immune cells could hold key to treating immune disorders
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Apr 02, 2012 |
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Researchers find beta cell stress could trigger the development of type 1 diabetes
In type 1 diabetes (T1D), pancreatic beta cells die from a misguided autoimmune attack, but how and why that happens is still unclear. Now, JDRF-funded scientists from the Indiana University School of Medicine have found ...
Diabetes
Mar 22, 2012 |
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Magnetic nanoparticles predict diabetes onset
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Immunology
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Study shows how the breakup of two proteins interferes with the immune system
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'Personalized immune' mouse offers new tool for studying autoimmune diseases
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Immunology
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Creating 'death-defying' insulin-producing islets for transplantation
Australian scientists have identified one way of making a frustratingly tricky transplant – of insulin-producing ‘islets of Langerhans’ into patients with Type 1 diabetes – more successful.
Medical research
Mar 13, 2012 |
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Study shows roles of beta cells and the immune system in Type 1 diabetes
A new JDRF-funded study shows that many of the genes known to play a role in type 1 diabetes (T1D) are expressed in pancreatic beta cells, suggesting that the cell responsible for producing insulin may be playing a part in ...
Diabetes
Mar 09, 2012 |
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Study finds some insulin production in long-term Type 1 diabetes
Massachusetts General Hospital (MGH) research has found that insulin production may persist for decades after the onset of type 1 diabetes. Beta cell functioning also appears to be preserved in some patients years after apparent ...
Diabetes
Feb 21, 2012 |
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As diabetes emerges, researchers track disease's first steps
Scientists have taken a remarkably detailed look at the initial steps that occur in the body when type 1 diabetes mellitus first develops in a child or young adult.
Diabetes
Feb 16, 2012 |
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Diabetes mellitus type 1 (Type 1 diabetes, T1DM, IDDM, or, formerly, juvenile diabetes) is a form of diabetes mellitus that results from autoimmune destruction of insulin-producing beta cells of the pancreas. The subsequent lack of insulin leads to increased blood and urine glucose. The classical symptoms are polyuria (frequent urination), polydipsia (increased thirst), polyphagia (increased hunger), and weight loss.
Incidence varies from 8-17/100,000 in Northern Europe and the U.S., with a high of about 35/100,000 in Scandinavia, to a low of 1/100,000 in Japan and China.
Eventually, type 1 diabetes is fatal unless treated with insulin. Injection is the most common method of administering insulin; other methods are insulin pumps and inhaled insulin. Pancreatic transplants have been used. Pancreatic islet cell transplantation is experimental, though growing.
Most people who develop type 1 are otherwise healthy. Although the cause of type 1 diabetes is still not fully understood, it is believed to be of immunological origin.
Type 1 can be distinguished from type 2 diabetes via a C-peptide assay, which measures endogenous insulin production.
Type 1 treatment must be continued indefinitely in all cases. Treatment is not intended to significantly impair normal activities, and can be done adequately if sufficient patient training, awareness, appropriate care, discipline in testing and dosing of insulin is taken. However, treatment remains quite burdensome for many people. Complications may be associated with both low blood sugar and high blood sugar, both largely due to the non-physiological manner in which insulin is replaced. Low blood sugar may lead to seizures or episodes of unconsciousness and requires emergency treatment. High blood sugar may lead to increased fatigue and can also result in long term damage to organs.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
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