Cancer Discovery
Cancer Discovery is a journal of the American Association for Cancer Research.
How some cancers 'poison the soil' to block metastasis
Cancer spread or metastasis can strike unprecedented fear in the minds of cancer patients. The "seed and the soil" hypothesis proposed by Stephen Paget in 1889 is now widely accepted to explain how cancer cells (seeds) are ...
Cancer
Apr 30, 2013 |
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Genetic biomarker may help identify neuroblastomas vulnerable to novel class of drugs
An irregularity within many neuroblastoma cells may indicate whether a neuroblastoma tumor, a difficult-to-treat, early childhood cancer, is vulnerable to a new class of anti-cancer drugs known as BET bromodomain inhibitors, ...
Cancer
Apr 09, 2013 |
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A hijacking of healthy cellular circuits
Proteins that control cell growth are often mutated in cancer, and their aberrant signaling drives the wild proliferation of cells that gives rise to tumors. One such protein, the epidermal growth factor receptor (EGFR), ...
Cancer
Apr 08, 2013 |
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Genetic vulnerability of lung cancer to lay foundation for new drug options
Physician-researchers at UT Southwestern Medical Center have identified a vulnerability of certain lung-cancer cells – a specific genetic weakness that can be exploited for new therapies.
Cancer
Apr 04, 2013 |
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Ganetespib shows potency against ALK-positive lung cancer and overcomes crizotinib resistance
A drug that indirectly impairs the function of several cancer-driving proteins, including anaplastic lymphoma kinase (ALK), may be an effective new treatment for patients with ALK—positive non-small cell lung cancer.
Cancer
Mar 26, 2013 |
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Research on immune-cell therapy could strengthen promising melanoma treatment
A new study of genetically modified immune cells by scientists from UCLA and the California Institute of Technology could help improve a promising treatment for melanoma, an often fatal form of skin cancer.
Cancer
Mar 22, 2013 |
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Functional characteristics of antitumor T cells change w increasing time after therapeutic transfer
Scientists have characterized how the functionality of genetically engineered T cells administered therapeutically to patients with melanoma changed over time. The data, which are published in Cancer Discovery, a journal of the ...
Cancer
Mar 21, 2013 |
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Biomarker may identify neuroblastomas with sensitivity to BET bromodomain inhibitors
Neuroblastoma, the most common malignant tumor of early childhood, is frequently associated with the presence of MYCN amplification, a genetic biomarker associated with poor prognosis. Researchers have determined that tumors ...
Cancer
Feb 21, 2013 |
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Emerging cancer drugs may drive bone tumors
Cancer drugs should kill tumors, not encourage their spread. But new evidence suggests that an otherwise promising class of drugs may actually increase the risk of tumors spreading to bone, according to researchers ...
Cancer
Feb 13, 2013 |
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Early results show two drugs may be better than one to treat most deadly skin cancer
Adding lung cancer drugs to targeted melanoma treatment could increase survival for certain patients, according to research published in Cancer Discovery today.
Cancer
Feb 12, 2013 |
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First-in-man study demonstrates the therapeutic effect of RNAi gene silencing in cancer treatment
A study led by Dr Josep Tabernero, the Director of Clinical Research at the Vall d'Hebron Institute of Oncology (VHIO) and Head of the Medical Oncology Department at the Vall d'Hebron University Hospital, shows for the first ...
Cancer
Feb 11, 2013 |
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Study finds potential to match tumors with known cancer drugs
When it comes to gene sequencing and personalized medicine for cancer, spotting an aberrant kinase is a home run. The proteins are relatively easy to target with drugs and plenty of kinase inhibitors already exist.
Cancer
Feb 05, 2013 |
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Scientists find a new way to boost common cancer drugs
Shutting down a specific pathway in cancer cells appears to improve the ability of common drugs to wipe those cells out, according to new research from scientists at Fox Chase Cancer Center, published in the January issue ...
Cancer
Jan 14, 2013 |
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Preventing prostate cancer through androgen deprivation may have harmful effects
Mice deficient in PTEN in the prostate developed stable precancers. Androgen deprivation promoted progression to invasive prostate cancer. Patients with PTEN-deficient prostate precancers may not benefit from androgen deprivation ...
Cancer
Dec 20, 2012 |
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Hard-to-treat Myc-driven cancers may be susceptible to drug already used in clinic
Drugs that are used in the clinic to treat some forms of breast and kidney cancer and that work by inhibiting the signaling molecule mTORC1 might have utility in treating some of the more than 15 percent of human cancers ...
Cancer
Dec 14, 2012 |
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