Cancer Research

Researchers find cause of chemotherapy resistance in melanoma

Researchers with UC Irvine's Chao Family Comprehensive Cancer Center have identified a major reason why melanoma is largely resistant to chemotherapy.

Cancer created Sep 17, 2012 | popularity not rated yet | comments 0 | with audio podcast

Cervical cancer and pre-cancer cervical growths require single HPV protein

(Medical Xpress)—Human papillomavirus (HPV) has long been implicated in cervical cancer, but details of how it happens have remained a mystery. Now researchers at the University of Wisconsin-Madison have found that a single ...

Cancer created Sep 17, 2012 | popularity not rated yet | comments 0 | with audio podcast

PARP inhibitors may have clinical utility in HER2-positive breast cancers

Poly (ADP-Ribose) polymerase (PARP) inhibitors, shown to have clinical activity when used alone in women with familial breast and ovarian cancers linked to BRCA mutations, may be a novel treatment strategy in women with HER2-positive ...

Cancer created Sep 17, 2012 | popularity not rated yet | comments 0 | with audio podcast

Lack of oxygen in cancer cells leads to growth and metastasis

(Medical Xpress)—It seems as if a tumor deprived of oxygen would shrink. However, numerous studies have shown that tumor hypoxia, in which portions of the tumor have significantly low oxygen concentrations, ...

Cancer created Sep 13, 2012 | popularity 5 / 5 (5) | comments 1 | with audio podcast

Researchers find acidic pH microenvironments in tumors aid tumor cell survival

Researchers at Moffitt Cancer Center and colleagues at the University of South Florida and Wayne State University have discovered that tumor cell survival relies on adaptation to acidic conditions in the tumor microenvironment. ...

Cancer created Sep 06, 2012 | popularity not rated yet | comments 0 | with audio podcast

Possible new therapy for the treatment of myeloma

(Medical Xpress)—Research from Karolinska Institutet shows that sorafenib, a drug used for advanced cancer of the kidneys and liver, could also be effective against multiple myeloma. The disease is one of the more common ...

Cancer created Sep 05, 2012 | popularity not rated yet | comments 0 | with audio podcast

New molecule with anti-cancer and anti-metastatic properties

A new molecule with anti-cancer and anti-metastatic properties has been discovered by teams from CNRS, CEA, the Institut Curie and Inserm, in collaboration with Australian and British researchers. This anticancer ...

Cancer created Sep 04, 2012 | popularity 5 / 5 (2) | comments 0

Possible therapy for tamoxifen resistant breast cancer identified

(Medical Xpress)—A study by researchers at the Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) has discovered how tamoxifen-resistant ...

Cancer created Aug 30, 2012 | popularity not rated yet | comments 0 | with audio podcast

Targeting inflammation to prevent, treat cancers

Researchers at the Georgia Health Sciences University Cancer Center have identified a gene that disrupts the inflammatory process implicated in liver cancer.

Cancer created Aug 22, 2012 | popularity not rated yet | comments 0 | with audio podcast

Combination therapy delivers one-two punch to skin cancer, boosting anti-tumor activity

(Medical Xpress) -- Treating metastatic melanoma by combining immunotherapy with a drug that inhibits the cancer-spreading activity of a common gene mutation significantly increased survival times in an animal model, according ...

Cancer created Aug 16, 2012 | popularity not rated yet | comments 0 | with audio podcast

Mechanisms of acquired chemoresistance in ovarian cancer identified

The presence of multiple ovarian cancer genomes in an individual patient and the absence or downregulation of the gene LRP1B are associated with the development of chemoresistance in women with the high-grade serous cancer ...

Cancer created Aug 15, 2012 | popularity 5 / 5 (1) | comments 0

Scientists devise new strategy to destroy multiple myeloma

Researchers at Virginia Commonwealth University Massey Cancer Center are reporting promising results from laboratory and animal experiments involving a new combination therapy for multiple myeloma, the second most common ...

Cancer created Aug 14, 2012 | popularity not rated yet | comments 0

TRPM7 protein key to breast cancer metastasis in animal models

The protein transient receptor potential melastatin-like 7 (TRPM7) is a critical determinant of breast cancer cell metastasis, according to study results published in Cancer Research, a journal of the American Association for Ca ...

Cancer created Aug 07, 2012 | popularity not rated yet | comments 0 | with audio podcast

Researchers find potential cancer roadblock

By identifying a key protein that tells certain breast cancer cells when and how to move, researchers at Michigan State University hope to better understand the process by which breast cancer spreads, or metastasizes.

Cancer created Aug 01, 2012 | popularity not rated yet | comments 0 | with audio podcast

Research identifies a promising new therapeutic target for aggressive breast cancer

Scientists at Western University have identified a new therapeutic target for advanced breast cancer which has shown tremendous promise in mouse models. The study led by Lynne-Marie Postovit of Western's Schulich School of ...

Cancer created Aug 01, 2012 | popularity not rated yet | comments 0 | with audio podcast