Blood transfusions associated with infection

July 31, 2009

A study of almost 25,000 coronary artery bypass graft (CABG) patients has shown that receiving blood from another person is associated with a two-fold increase in post-operative infection rates. The research, published in the open access journal BMC Medicine, also found considerable hospital variation in transfusion practices.

Mary Rogers, from the University of Michigan, USA, led a team of researchers who carried out the study. She said, "Clearly, blood transfusions are vital in the treatment of some conditions, such as life-threatening bleeding. However, over the past several decades a body of evidence has accumulated that indicates various adverse effects in patients who receive transfusions, particularly with exposure to allogeneic blood".

The researchers sought to assess hospital variation in blood use and outcomes in patients, to see if unnecessary blood transfusions may be putting the safety of some patients at risk. Overall, 30% of the variation in transfusion practices was found to be attributable to the hospital where the CABG was performed. According to Rogers, "The safety of patients undergoing CABG will likely be improved if hospitals carefully review current guidelines on allogeneic , closely adhere to such guidelines, and institute interventions to reduce inappropriate use of blood transfusions in recipients of CABG".

More information: Hospital variation in transfusion and infection after cardiac surgery: a cohort study, Mary A. M. Rogers, Neil Blumberg, Sanjay Saint, Kenneth M. Langa and Brahmajee K. Nallamothu, BMC Medicine (in press), www.biomedcentral.com/bmcmed/

Source: BioMed Central (news : web)

Related Stories

Recommended for you

TET proteins drive early neurogenesis

December 7, 2016

The fate of stem cells is determined by series of choices that sequentially narrow their available options until stem cells' offspring have found their station and purpose in the body. Their decisions are guided in part by ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.