Researchers demonstrate that 'safe' cigarettes are as hazardous as tobacco

May 12, 2010

Using the same technique they developed to document the harmful effects of tobacco products, a team of researchers found that cigarettes made without tobacco or nicotine may be more carcinogenic because they actually induce more extensive DNA damage than tobacco products. The technique has been awarded U.S. patent No. 7,662,565.

The research team was led by Zbigniew Darzynkiewicz, M.D., Ph.D., professor of pathology. Their study, "DNA damage response induced by exposure of human lung adenocarcinoma cells to smoke from tobacco- and nicotine-free cigarettes," will appear in the June 1 issue of Cell Cycle (Volume 9, Issue 11).

Using laser scanning cytometry (LSC) technology to measure DNA damage response to the smoke from commercially available tobacco- and nicotine-free cigarettes, the research team expected to find the alternative products were less hazardous than regular tobacco cigarettes. However, their data suggest that exposure of cells to smoke from tobacco- and nicotine-free cigarettes leads to formation of double-strand DNA breaks (DSBs). Since DSBs are potentially carcinogenic, the data indicate that smoking tobacco- and nicotine-free cigarettes is at least as hazardous as those containing tobacco and .

The authors conclude that their methodology to assess the potential carcinogenic properties of , based on measurement of DNA damage response as assessed by LSC, provides a useful addition to the battery of genotoxic tests for probing hazards. Such tests, which can be applied to evaluate the effects of cigarettes and cigarette surrogate products on human health, can be important tools for regulatory agencies such as the or, in the case of environmental smoke, by the .

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not rated yet May 12, 2010
Smokeless cigarettes have nicotine and glycerin in them.
The glycerin is to make a smoke like visible vapor.
If the nicotine produces genetic damage, we better stop using nicotine patches, unless the claim is that glycerin causes genetic damage.
not rated yet May 12, 2010
I think this article is still referring to combustible products like Smoke-Free that use other plant materials than tobacco(coffee bean husks are popular I believe). I don't believe they are talking about the E-Cig vaporizers, which don't actually combust any plant materials. I still think it is the ash and tar that cause most of the problems, genetically or otherwise.
not rated yet May 13, 2010
What about the devices that just use a vapor of nicotine and contain no tar or smoke? Are these any safer?

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