New compounds show promise against hepatitis C infection
Two bioflavonoids, catechin and naringenin, have displayed antiviral activity on tissue culture infected with Hepatitis C.
Approximately 270-300 million people worldwide are infected with hepatitis C, and about 1%-2% of the U.S. population is infected. This infectious disease can lead to scarring of the liver, cirrhosis, and eventually liver failure. A significant number of infected patients develop liver disease or cancer. The current standard treatment is interferon, which has only a 50% success rate. Compounding the 50% failure rate are severe side effects which lead many people to discontinue treatment.
Dr. Samuel Wheeler French Jr., MD, PhD, Assistant Professor of Pathology and Laboratory Medicine at UCLA and researcher at UCLA's Jonsson Comprehensive Cancer Center, is a liver pathologist who is currently developing a proteomic-based program to study the development of liver cancer from hepatitis C viral infection. His most recent study results, to be presented in an American Society for Investigative Pathology (ASIP) symposium on "Pathobiology of Liver Injury and Fibrosis" on Tuesday afternoon, April 12 at Experimental Biology 2011, evaluate the effects of several flavonoids on hepatitis C viral infection. Previously, Dr. French has shown that quercetin, a plant-derived bioflavonoid used by some as a nutritional supplement, attenuates Hepatitis C virus production with no cell toxicity. In his most recent research, French and colleagues found that two other bioflavonoids, catechin and naringenin, displayed antiviral activity on tissue culture. The next step is to determine through a Phase I Clinical Trial that they are safe for patients with chronic hepatitis C infection.
"We now have several new compounds we can test to see if they reduce virus infection," said Dr. French. "The positive thing about this family of compounds is that they are nontoxic, and can be taken at high doses. Bioflavonoids represent a very promising therapy with very few side effects that could help millions of people."
- Natural compound blocks hepatitis C infection Jan 05, 2010 | not rated yet | 0
- Interferon as long-term treatment for hepatitis C not effective Dec 04, 2008 | not rated yet | 0
- Treatment for advanced hepatitis C doesn't work, researchers find Dec 03, 2008 | not rated yet | 0
- New treatment for hepatitis C May 14, 2008 | not rated yet | 0
- Hepatitis B virus triggers cell 'suicide' in patients with chronic infection Apr 08, 2008 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Classical and Quantum Mechanics via Lie algebras
Apr 15, 2011 I'd like to open a discussion thread for version 2 of the draft of my book ''Classical and Quantum Mechanics via Lie algebras'', available online at http://lanl.arxiv.org/abs/0810.1019 , and for the...
- More from Physics Forums - Independent Research
More news stories
No new human cases of the H7N9 virus have been recorded in China for a week, national health authorities said, for the first time since the outbreak began in March.
Diseases, Conditions, Syndromes 1 hour ago | not rated yet | 0
A Nobel prize-winning scientist Tuesday played down "shock-horror scenarios" that a new virus strain will emerge with the potential to kill millions of people.
Diseases, Conditions, Syndromes 1 hour ago | 5 / 5 (1) | 0
Bacteria resistant to the antibiotic colistin are also commonly resistant to antimicrobial substances made by the human body, according to a study in mBio, the online open-access journal of the American Society for Microb ...
Diseases, Conditions, Syndromes 6 hours ago | 5 / 5 (1) | 0
(AP)—Federal investigators probing the hantavirus outbreak blamed for three deaths at Yosemite National Park recommend that design changes to tent cabins and other lodging run by private concessionaires first be reviewed ...
Diseases, Conditions, Syndromes 12 hours ago | not rated yet | 0
A new diagnostic test for a worm infection that can lead to severe enlargement and deformities of the legs and genitals is far more sensitive than the currently used test, according to results of a field ...
Diseases, Conditions, Syndromes 12 hours ago | not rated yet | 0 |
Each day, an average of nine people are killed in the United States and more than 1,000 injured by drivers doing something other than driving.
8 minutes ago | not rated yet | 0
(Medical Xpress)—We spend about a third of our life asleep, but why we need to do so remains a mystery. In a recent publication, researchers at University of Surrey and University College London suggest a new hypothesis, ...
3 minutes ago | not rated yet | 0
Johns Hopkins researchers say they have discovered specific chemical alterations in two genes that, when present during pregnancy, reliably predict whether a woman will develop postpartum depression.
2 hours ago | not rated yet | 0 |
(Medical Xpress)—A three-year multinational study has tracked and detailed the progression of Huntington's disease (HD), predicting clinical decline in people carrying the HD gene more than 10 years before ...
30 minutes ago | not rated yet | 0
Children who have suffered maltreatment are 36% more likely to be obese in adulthood compared to non-maltreated children, according to a new study by King's College London. The authors estimate that the prevention or effective ...
2 hours ago | not rated yet | 0