Combined imaging agents advance PET imaging of cancer
Research presented at SNM's 58th Annual Meeting is taking targeted molecular imaging to a new level by combining two commonly used imaging agents into one molecular imaging procedure. The combination of these agents creates a comprehensive examination of the extent of cancer spread within a variety of organ systems in the body.
"During a time when health care costs are under intense scrutiny, consolidated procedures such as this one that provide comprehensive imaging data are a benefit to everyoneto clinicians, healthcare administrators and especially patients who would need only one scan instead of two," says Andrei Iagaru, MD, lead author of the study and assistant professor of radiology and nuclear medicine at Stanford University Medical Center, Stanford, Calif. "What we stand to gain from combining these two agents is the diversification of tumor targeting. The beauty of it is that each agent has its own strength, and those are unified in the imaging. In combination they represent a powerful new tool for acquiring as much information as possible about the extent of a patient's cancer."
The objective of the study was to gauge the value of combining two molecular imaging agents for cancer imaging with a hybrid molecular imaging system. Researchers used a positron emission tomography and computed tomography (PET/CT) system, which combines both nuclear medicine and X-ray technology to produce images that provide information about both physiological processes and structural anatomy.
All PET imaging agents are not alike. Medical isotopes are often labeled with an antibody, peptide or any number of other useful molecules that guide the medical isotope directly to its target. One of the most prevalently used imaging agents is 18F-Fluorodeoxyglucose (18F FDG), a glucose analog that is metabolized by cells as fuel. This is useful because cancer cells are metabolically hyperactive compared to healthy cells. PET imaging with 18F FDG will show these areas of increased metabolism as "hot spots" on scans. But while it is an excellent agent, it can still miss some cancer lesions, such as those in the skeleton. For this study, researchers compare the results of 18F FDG and sodium fluoride-18 (18F NaF), another PET imaging agent that has been shown to provide superior functional imaging of skeletal tissue, both separately and together.
For this prospective study investigators recruited 78 patients with proven cancers and scanned them separately using 18F NaF PET/CT and 18F FDG PET/CT imaging methods. Participants then received a third PET/CT scan using 18F NaF and 18F FDG simultaneously. Results of all three imaging studies were then analyzed for their usefulness in evaluating tumor malignancy. Researchers found that combined 18F NaF and 18F FDG PET/CT imaging provided good-quality imaging of both skeletal and extra-skeletal malignant lesions from breast, lung, colorectal and other cancers.
Combined 18F NaF and 18F FDG PET/CT is a comprehensive new imaging procedure for cancer staging without any additional risk of toxicity. In fact, this technique reduces overall radiation dose due to the consolidation of imaging. With further demonstration of its clinical value, this imaging technique could become widely available for evaluating a host of different cancers in order to improve treatment planning and patient prognosis.
More information: Scientific Paper 34: A. Iagaru, E. Mittra, M. Sathekge, V. Prakash, V. Iyer, D. Dick, P. Lapa, J. Isidoro, J. de Lima, S. Gambhir, Stanford University Medical Center, Stanford, CA; University of Pretoria, Pretoria, South Africa; Aalborg University Hospital, Aalborg, Denmark; University Hospital of Coimbra, Coimbra, Portugal; "Combined 18F NaF and 18F FDG PET/CT: Initial results of a multi-center trial," SNM's 58th Annual Meeting, June 4-8, 2011, San Antonio, TX.
Provided by Society of Nuclear Medicine
- Researchers identify possible imaging method to stratify breast cancer without biopsy Dec 17, 2009 | not rated yet | 0
- Fewer guessing games for lung cancer patients Dec 06, 2010 | not rated yet | 0
- Blood-sugar lowering medications may increase risk for false positive results in cancer screenings Jun 07, 2010 | not rated yet | 0
- Personalized medicine: Molecular imaging predicts treatment success in many cancers Sep 01, 2010 | not rated yet | 0
- Coming soon: 3-D imaging that flies 'through' and 'around' cancer Jul 14, 2006 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Pressure-volume curve: Elastic Recoil Pressure don't make sense
May 18, 2013 From pressure-volume curve of the lung and chest wall (attached photo), I don't understand why would the elastic recoil pressure of the lung is...
If you became brain-dead, would you want them to pull the plug?
May 17, 2013 I'd want the rest of me to stay alive. Sure it's a lousy way to live but it beats being all-the-way dead. Maybe if I make it 20 years they'll...
MRI bill question
May 15, 2013 Dear PFers, The hospital gave us a $12k bill for one MRI (head with contrast). The people I talked to at the hospital tell me that they do not...
Ratio of Hydrogen of Oxygen in Dessicated Animal Protein
May 13, 2013 As an experiment, for the past few months I've been consuming at least one portion of Jell-O or unflavored Knox gelatin per day. I'm 64, in very...
Alcohol and acetaminophen
May 13, 2013 Edit: sorry for the typo in the title , can't edit I looked around on google quite a bit and it's very hard to find precise information on the...
Marie Curie's leukemia
May 13, 2013 Does anyone know what might be the cause of Marie Curie's cancer
- More from Physics Forums - Medical Sciences
More news stories
In a new study described in the journal Oncogene, researchers reveal how a key player in cell growth, immunity and the inflammatory response can be transformed into a primary contributor to tumor growth.
Cancer 2 hours ago | not rated yet | 0 |
A new study conducted using extensive medical records of over one million Israeli adolescents before military service shows clearly how exposure to the Israeli sun of young, light-skinned children increases substantially ...
Cancer 4 hours ago | not rated yet | 0
A new measure of the heterogeneity – the variety of genetic mutations – of cells within a tumor appears to predict treatment outcomes of patients with the most common type of head and neck cancer. In the May 20 issue ...
Cancer 8 hours ago | not rated yet | 0
Researchers at Mayo Clinic have developed a promising method to distinguish between pancreatic cancer and chronic pancreatitis—two disorders that are difficult to tell apart. A molecular marker obtained from pancreatic ...
Cancer 8 hours ago | not rated yet | 0
The use of a smartphone application significantly improves patients' preparation for a colonoscopy, according to new research presented today at Digestive Disease Week (DDW). The preparation process, which begins days in ...
Cancer May 19, 2013 | not rated yet | 0
A new computer model could help scientists predict when a particular strain of avian influenza might become infectious from bird to human, according to a report to be published in the International Journal Data Mining an ...
24 minutes ago | not rated yet | 0
Researchers at Lund University in Sweden have mapped the significance of heredity for common forms of atherosclerotic disease. No studies have previously examined whether different forms of the disease share heredity.
20 minutes ago | not rated yet | 0
It is impossible to predict the evolution of China's human H7N9 bird flu outbreak as researchers are still trying to understand the source of human transmission, the head of the World Health Organisation said Monday.
3 minutes ago | not rated yet | 0
Federal health regulators say an experimental insomnia drug from Merck can help patients fall asleep, but it also carries worrisome side effects, including daytime drowsiness and suicidal thinking.
17 minutes ago | not rated yet | 0
Over the past few decades, neuroscientists have made much progress in mapping the brain by deciphering the functions of individual neurons that perform very specific tasks, such as recognizing the location ...
2 hours ago | 5 / 5 (1) | 0 |
There is a link between use of anabolic-androgenic steroids and reduced mental health later in life. This is the main conclusion of a new study on elite male strength athletes that researchers from the University of Gothenburg ...
1 hour ago | not rated yet | 0