Older age does not cause testosterone levels to decline in healthy men

A decline in testosterone levels as men grow older is likely the result—not the cause—of deteriorating general health, say Australian scientists, whose new study finds that age, in itself, has no effect on testosterone level in healthy older men.

The results, to be presented Tuesday at The Endocrine Society's 93rd Annual Meeting in Boston, are the first findings released from the Healthy Man Study, according to principal investigator David Handelsman, MD, PhD, professor and director of the ANZAC Research Institute at the University of Sydney.

"Some researchers believe that an age-related testosterone deficiency contributes to the deteriorating health of older men and causes nonspecific symptoms, such as tiredness and loss of libido," he said.

Handelsman and his team, however, found that serum (blood) testosterone levels did not decline with increasing in older men who reported being in excellent health with no symptoms to complain of.

"We had originally expected age to have an effect on serum testosterone, so the findings were a bit of a surprise," Handelsman said.

Two study centers in Australia recruited 325 men over the age of 40 (median age, 60) who had self-reported excellent health and no symptom complaints. To test blood testosterone levels, the researchers took blood samples from the men nine times over three months. They excluded men from the study who took medications that affect testosterone.

Obesity caused a mild and clinically unimportant lowering of blood testosterone levels, the investigators reported. Age had no effect on testosterone level.

"The modest decline in blood testosterone among older men, usually coupled with nonspecific symptoms, such as easy fatigue and low sexual desire, may be due to symptomatic disorders that accumulate during aging, including obesity and heart disease," he said. "It does not appear to be a hormone deficiency state."

The message for patients and their doctors, Handelsman said, is " with low do not need therapy unless they have diseases of their pituitary or testes."

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