Mom's lead exposure linked to higher blood pressure in their daughters
(Medical Xpress) -- Prenatal lead exposure is linked to a greater risk of high blood pressure in teen girls, but not in boys, a new study from the University of Michigan shows.
"This study suggests that a common chemical pollutantleadcan build up in mom's bones and then increase their daughter's risk of developing hypertension, the most important risk factor for stroke and heart disease," said Howard Hu, professor at the U-M School of Public Health and lead study author. "It further increases the importance of reducing such exposures. It also significantly increases the pressure to study how such risks get transferred so we can develop better methods of treatment, including better drugs."
Researchers used data from the Early Life Exposures in Mexico to Environmental Toxicants project to examine the relationship between prenatal lead exposure and blood pressure in 457 children ages 7-15. Researchers measured the lead accumulations in both bone and in the umbilical cords of mothers in the study.
Among female offspring, a 13 ug/g increase in maternal tibia lead was associated with an increase of 2.11 mm Hg in systolic blood pressure, and an increase of 1.60 mm Hg in diastolic blood pressure. To put those numbers in perspective, Hu said, consider that previous studies have shown that a 2 mm Hg increase in systolic blood pressure results in a 7 percent increase in the risk of death due to ischemic heart disease and a 10 percent increase in the risk of death due to stroke.
This is the first study to examine the association of a mother's bone lead levels with blood pressure in her children. The significant gender disparity surprised researchers, Hu said.
"We had not previously seen a gender disparity in lead's impact on blood pressure, and had published studies showing that adult lead exposure was a risk factor for hypertension in both adult men and women" Hu said. "But there's been an increasing amount of evidence for gender differences in susceptibility to environmental toxicants, and our study suggests this is true for offspring when the exposure is prenatal, meaning from mom's bones."
It's been long known that the prevalence of hypertension and heart disease differs between men and women, but scientists don't know why.
"This promises to shed light on causes of hypertension, for which there currently remains relatively little insight based on many genetic studies and other studies of risk factors in adults," Hu said.
The findings could mean that higher bone lead in mothers may result in increased risk of hypertension in the women, themselves, but also affect the cardiovascular health of their daughters, and it also highlights the need for secondary preventative measures, such as dietary calcium supplementation.
Hu noted that the study doesn't mean that boys are totally exempt from lead exposure in utero.
"Given that this is the first study to investigate these relationships using the methods we used, it really needs to be reproduced and in other populations before one can conclude that boys are less susceptible."
Provided by University of Michigan
- Systolic and diastolic blood pressures together more useful for predicting cardiovascular risk Feb 18, 2009 | not rated yet | 0
- Prenatal exposure to tobacco smoke raises blood pressure in infants Jul 30, 2007 | not rated yet | 0
- Smoking and high blood pressure: a double blow for bleeding stroke risk Mar 06, 2008 | not rated yet | 0
- Calcium during pregnancy reduces harmful blood lead levels Sep 09, 2008 | not rated yet | 0
- Smoking around your kindergartner could raise their blood pressure Jan 10, 2011 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Classical and Quantum Mechanics via Lie algebras
Apr 15, 2011 I'd like to open a discussion thread for version 2 of the draft of my book ''Classical and Quantum Mechanics via Lie algebras'', available online at http://lanl.arxiv.org/abs/0810.1019 , and for the...
- More from Physics Forums - Independent Research
More news stories
People eating at fast food restaurants largely underestimate the calorie content of meals, especially large ones, according to a paper published today in BMJ.
Health 9 hours ago | not rated yet | 0
Don't doubt it when a woman harried by hot flashes says she's having a hard time remembering things. A new study published online in Menopause, the journal of The North American Menopause Society (NAMS), helps confirm with o ...
Health 10 hours ago | not rated yet | 0
The Senate has overwhelmingly rejected an amendment allowing states to require labeling of genetically modified foods.
Health 11 hours ago | not rated yet | 1
(AP)—McDonald's once again faced criticism that it's a purveyor of junk food that markets to children at its annual shareholder meeting Thursday.
Health 11 hours ago | not rated yet | 0
Can economic incentives such as gift cards, T-shirts, and time off from work motivate members of the public to increase their donations of blood?
Health 13 hours ago | not rated yet | 0 |
(Medical Xpress)—Regulating the distribution of power in neurons is done by a system that makes the national electric grid look simple by comparison. Each neuron has several thousand mitochondria confined ...
10 hours ago | 4.8 / 5 (5) | 0 |
A brief visual task can predict IQ, according to a new study. This surprisingly simple exercise measures the brain's unconscious ability to filter out visual movement. The study shows that individuals whose ...
15 hours ago | 4.5 / 5 (10) | 1 |
Teams of highly respected Alzheimer's researchers failed to replicate what appeared to be breakthrough results for the treatment of this brain disease when they were published last year in the journal Science.
13 hours ago | 5 / 5 (1) | 2 |
Scientists at the National Institutes of Health report they have discovered in mouse studies that a small molecule released in the spinal cord triggers a process that is later experienced in the brain as ...
13 hours ago | 5 / 5 (2) | 0 |
Little is known about why asthma develops, how it constricts the airway or why response to treatments varies between patients. Now, a team of researchers at Weill Cornell Medical College, Columbia University Medical Center ...
14 hours ago | not rated yet | 0 |
Ethnic background plays a surprisingly large role in how diabetes develops on a cellular level, according to two new studies led by researchers at the Stanford University School of Medicine.
11 hours ago | not rated yet | 0 |