Research provides unprecedented insight into fighting viral infections

Researchers at Rutgers and UMDNJ-Robert Wood Johnson Medical School have determined the structure of a protein that is the first line of defense in fighting viral infections including influenza, hepatitis C, West Nile, rabies, and measles.

Principal investigators of the study, "Structural basis of RNA recognition and activation by innate immune receptor RIG-I," chosen for advanced online publication in Nature, say the research is key in the development of broad-based to combat viral infections.

"Understanding innate immunity to viral infections is crucial to developing drugs that can fight viruses or control inflammation," said Joseph Marcotrigiano, assistant professor of chemistry and at Rutgers who along with Smita Patel, professor of biochemistry at Robert Wood Johnson Medical School, are on the newly released study. "Having this foundation is extremely important."

RIG-I is a receptor protein that recognizes differences in molecular patterns in order to differentiate – the process during which virus particles makes new copies of themselves within a host cell and can then infect other cells – -- from cellular RNA. What researchers discovered is that viral RNA, as opposed to single-stranded cellular RNA, is a double-stranded structure. This double-stranded difference is the reason the RIG-I protein recognizes it and initiates a signal to induce anti-immune and anti-inflammatory defenses within the cell.

Prior to this research, there was little information on how RIG-I protein recognized the viral infections, said Patel. "A failure of RIG-I to identify viral RNA can lead to alterations of the cell, including cell death, inflammation, autoimmune diseases, and cancer," he said.

This is a first step, the scientists say, in helping to develop therapies that interfere with a broad variety of viral infections – a major breakthrough for millions of people who get sick from viral infections which cannot be treated effectively by current medication.

"This work provides unprecedented insights on the molecular mechanism of viral RNA recognition by RIG-I," said Barbara Gerratana, who oversees enzyme catalysis grants at the National Institute of General Medical Sciences of the National Institutes of Health. "As a result, we have a deeper understanding of how the human body fights a structural basis of the development of new anti-viral therapeutics."

Related Stories

Researchers discover how cells recognize viral toxin

Mar 25, 2010

(PhysOrg.com) -- For many years it's been known that the fever, achiness and other symptoms you feel during the flu are triggered by a viral molecule that travels through the body acting like a toxin.

Researchers discover Ebola's deadly secret

Jan 19, 2010

(PhysOrg.com) -- Research at Iowa State University has led scientists to uncover how the deadly Zaire Ebola virus decoys cells and eventually kills them.

Recommended for you

Leeches help save woman's ear after pit bull mauling

5 hours ago

(HealthDay)—A pit bull attack in July 2013 left a 19-year-old woman with her left ear ripped from her head, leaving an open wound. After preserving the ear, the surgical team started with a reconnection ...

New pain relief targets discovered

17 hours ago

Scientists have identified new pain relief targets that could be used to provide relief from chemotherapy-induced pain. BBSRC-funded researchers at King's College London made the discovery when researching ...

Building 'smart' cell-based therapies

17 hours ago

A Northwestern University synthetic biology team has created a new technology for modifying human cells to create programmable therapeutics that could travel the body and selectively target cancer and other ...

User comments