Drospirenone-containing contraceptives linked to higher risk of blood clots
The use of drospirenone-containing oral birth control pills is linked to a significantly higher risk of blood clots, both deep vein thrombosis and pulmonary embolism, according to an article in the Canadian Medical Association Journal.
All oral contraceptives are associated with a higher risk of blood clots, but there is conflicting information about the risk of adverse events with drospirenone. Many previous studies have evaluated risks of second- and third-generation contraceptives, which both contain derivatives of testosterone. Israeli researchers undertook a study to determine the risk of venous and arterial blood clots in various oral contraceptive users. They looked at data on 329 995 women in Israel aged 12 to 50 years who received oral contraceptives between January 2002 and December 2008 and followed them until 2009. There were 431 223 total use episodes.
The researchers found an elevated risk of venous thrombotic events for drospirenone users compared with second- and third-generation contraceptives. Risk was highest in the early months of use. A noticeable trend was a major increase in prescribing drospirenone-combined contraceptives over the years and a decline in use of second-generation contraceptives. Drospirenone has been marketed as causing less weight gain and edema than other birth control pills.
"Use of drospirenone-containing combined oral contraceptives was associated with a significantly increased risk of venous thrombotic events (deep vein thrombosis and pulmonary embolism) but not arterial thrombotic events (transient ischemic attack and cerebrovascular accident), relative to use of second- or third-generation combined oral contraceptives," states Dr. Naomi Gronich, Pharmacoepidemiology and Pharmacogenetics Unit, Department of Community Medicine and Epidemiology, Office of Chief Physician, Clalit Health Services Headquarters, Tel Aviv, Israel, with coauthors.
A US Federal Drug Agency (FDA) study released Oct. 27 warns of the increased risk of blood clots linked to drospirenone-containing oral contraceptives. The FDA will discuss the risks and benefits of these contraceptives at a meeting of the Reproductive Health Drugs Advisory Committee and the Drug Safety and Risk Management Advisory Committee on Dec. 8, 2011.
"With the increasing use of drospirenone-containing contraceptives, it is important to raise awareness of the increased, albeit small, risk of venous thromboembolism relative to third-generation pills, especially among those who are older or obese," the authors conclude.
In a related commentary, Dr. Susan Solymoss, McGill University, states "the study by Gronich and colleagues adds further evidence of a higher relative risk of venous thromboembolism among women taking this type of oral contraceptive, relative to the alternatives of either third- or second-generation oral contraceptives."
She notes that recent well-designed studies of drospirenone have shown a higher risk of blood clots compared with earlier articles that did not identify an elevated risk.
Provided by Canadian Medical Association Journal
- Studies show increased risk of blood clots when taking oral contraception with drospirenone Apr 21, 2011 | not rated yet | 0
- Study confirms some contraceptive pills more likely to cause blood clots Oct 25, 2011 | not rated yet | 0
- Newer oral contraceptive as safe for gall bladder as older birth-control pills: research Apr 18, 2011 | not rated yet | 0
- US reviews birth control pill safety over clot risk May 31, 2011 | not rated yet | 0
- Some birth control shows higher clot risk: US Oct 28, 2011 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Classical and Quantum Mechanics via Lie algebras
Apr 15, 2011 I'd like to open a discussion thread for version 2 of the draft of my book ''Classical and Quantum Mechanics via Lie algebras'', available online at http://lanl.arxiv.org/abs/0810.1019 , and for the...
- More from Physics Forums - Independent Research
More news stories
Gourmands and foodies everywhere have long recognized ginger as a great way to add a little peppery zing to both sweet and savory dishes; now, a study from researchers at Columbia University shows purified components of the ...
Diseases, Conditions, Syndromes 16 minutes ago | not rated yet | 0
There are significant cost and risk factors associated with two procedures commonly used to diagnose or treat gastrointestinal problems, according to research presented at Digestive Disease Week (DDW).
Diseases, Conditions, Syndromes 12 hours ago | not rated yet | 0
Regular consumption of coffee is associated with a reduced risk of primary sclerosing cholangitis (PSC), an autoimmune liver disease, Mayo Clinic research shows. The findings were being presented at the Digestive Disease ...
Diseases, Conditions, Syndromes 12 hours ago | not rated yet | 0 |
A new case of the deadly coronavirus has been detected in Saudi Arabia where 15 people have already died after contracting it, the health ministry announced on Saturday on its Internet website.
Diseases, Conditions, Syndromes May 18, 2013 | not rated yet | 0
(HealthDay)—Few randomized clinical trials have been done to assess clinical prediction rules for patients with lower back pain, and the trials that have been done are of low quality and do not provide ...
Diseases, Conditions, Syndromes May 17, 2013 | not rated yet | 0 |
Researchers at the University of Wisconsin have identified a potential new risk factor for obstructive sleep apnea: asthma. Using data from the National Institutes of Health (Heart, Lung, and Blood Institute)-funded Wisconsin ...
16 minutes ago | not rated yet | 0 |
A new study looking at sleep-disordered breathing (SDB) and markers for Alzheimer's disease (AD) risk in cerebrospinal fluid (CSF) and neuroimaging adds to the growing body of research linking the two.
26 minutes ago | not rated yet | 0 |
In their quest to learn more about the variability of cells between and within tissues, biomedical scientists have devised tools capable of simultaneously measuring dozens of characteristics of individual ...
1 hour ago | not rated yet | 0 |
Scientists at Johns Hopkins have turned their view of osteoarthritis (OA) inside out. Literally. Instead of seeing the painful degenerative disease as a problem primarily of the cartilage that cushions joints, ...
1 hour ago | 5 / 5 (1) | 0 |
The hunt for an HIV vaccine has gobbled up $8 billion in the past decade, and the failure of the most recent efficacy trial has delivered yet another setback to 26 years of efforts.
5 hours ago | not rated yet | 0
The devastating effect of Alzheimer's disease on bilingual people has been thrown into focus in Canada, where the sudden loss of a second language can leave sufferers feeling like strangers in their own country.
3 hours ago | not rated yet | 0