Human 'shock absorbers' discovered

February 14, 2012
Professor Tony Weiss, from the School of Molecular Bioscience, leads and coordinates the research team who made this groundbreaking discovery

(Medical Xpress) -- An international team of scientists, led by the University of Sydney, has found the molecular structure in the body which functions as our 'shock absorber'.

The discovery of the previously unknown part of the molecule will be applied to the researchers' work on designing improved versions of a human blood vessel and on repairing , including burns.

The research can be applied to treating cardiovascular disease and emphysema.

The findings are published in today's edition of the (PNAS).

"This exciting discovery answers the mystery of how our bodies accommodate our living tissue without it being torn to shreds by its interaction with so many moving parts," said Professor Tony Weiss, from the University's School of , who leads and coordinates the research team.

The team dissected a key part of the molecule in elastin, the protein that keeps tissues such as skin, lungs and blood vessels elastic during normal processes such as body movement, breathing and .

Using a high-powered combination of synchronised X-ray beams and elastin synthesis tools, the team discovered that human elastin contains a molecular bridge or 'shock absorber'.

"This tiny neatly connects specialised molecular parts: one part is dedicated to elasticity and another part dedicated to binding living tissue," Professor Weiss said.

"It performs the same function for humans at a molecular level as shock absorbers do in a car; we can enjoy a smooth ride because they keep the body of the car from being violently rattled by the movement of the wheels."

The team now has sufficient information to change just a billionth of a metre of the molecular bridge, which would result in dramatic changes to the elastin.

The produced an elastin which looks and behaves differently to normal elastin.

"This finding will benefit our work on designing artificial blood vessels that use replicas of human elastin, to repair and replace human blood vessels, with implications for the treatment of cardiovascular disease," Professor Weiss said.

"In the future it may have applications in treating emphysema, which is caused by destruction to lung elastin."

The research was conducted as part of the University's new centre that aims to reduce the personal and social burden of obesity, diabetes and worldwide by transforming the way people eat, work and live.

The fact the team is composed of leading researchers from Australia, the United Kingdom and Europe, with access to a variety of exquisite hi-tech tools, means the research can use their collective input.

"An important part of this outstanding work was also done by Giselle Yeo, a superb student in my lab," Professor Weiss said.

Explore further: Engineered Blood Vessels Function like Native Tissue

More information: www.pnas.org/

Related Stories

Engineered Blood Vessels Function like Native Tissue

July 5, 2007

Blood vessels that have been tissue-engineered from bone marrow adult stem cells may in the future serve as a patient's own source of new blood vessels following a coronary bypass or other procedures that require vessel replacement, ...

New potential to treat chronic obstructive pulmonary disease

January 27, 2010

Chronic obstructive pulmonary disease (COPD) is defined by emphysema and/or chronic bronchitis. It destroys the normal architecture of the lung and inhibits the mechanical aspects of breathing, which prevents necessary gas ...

Solving the riddle of nature's perfect spring

March 1, 2011

(PhysOrg.com) -- Scientists have unravelled the shape of the protein that gives human tissues their elastic properties in what could lead to the development of new synthetic elastic polymers.

Recommended for you

Basic research fuels advanced discovery

August 26, 2016

Clinical trials and translational medicine have certainly given people hope and rapid pathways to cures for some of mankind's most troublesome diseases, but now is not the time to overlook the power of basic research, says ...

New avenue for understanding cause of common diseases

August 25, 2016

A ground-breaking Auckland study could lead to discoveries about many common diseases such as diabetes, cancer and dementia. The new finding could also illuminate the broader role of the enigmatic mitochondria in human development.

New method creates endless supply of kidney precursor cells

August 25, 2016

Salk Institute scientists have discovered the holy grail of endless youthfulness—at least when it comes to one type of human kidney precursor cell. Previous attempts to maintain cultures of the so-called nephron progenitor ...

3 comments

Adjust slider to filter visible comments by rank

Display comments: newest first

Telekinetic
1 / 5 (1) Feb 14, 2012
Don't forget to to take your Vitamin C if you want to help your system along with elastin production.
Callippo
1 / 5 (1) Feb 14, 2012
....groundbreaking discovery... ...exciting discovery... ..outstanding work..
.um, um.. the author of this news must be really something...
localcooling
1 / 5 (1) Feb 22, 2012
Part of being a "skilled" researcher is to have way above average marketing skills.

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.