Scientists collaborate in discovery of new targets for the treatment of asthma

February 27, 2012

A collaboration between scientists in Trinity College Dublin and the United Kingdom has identified new processes that lead to the development of a novel cell implicated in allergies. The discovery has the potential for new strategies to treat asthma and other allergic diseases. The research findings have just been published in the leading international journal Nature Immunology.

The work was performed by Professor Padraic Fallon, Science Foundation Ireland Stokes Professor of Translational Immunology of TCD's School of Medicine and Dr Andrew McKenzie of the Medical Research Council Laboratory for Molecular Biology in Cambridge.

The number of people with allergic disease, such as asthma and , is increasing globally with Irish children having the fourth highest incidence of asthma in the world. A major area of research in developing new strategies to treat is directed towards increasing understanding of the processes and cells involved that cause .

The video will load shortly

Professor Fallon and colleagues previously discovered a new white blood cell, the nuocyte, that initiates the early generation of the immune responses that can lead to asthma or other allergic conditions. In this study, a new pathway for the development of nuocytes was identified and a transcription factor, RORalpha, was shown to be critical for both the generation of nucoytes and allergic-like inflammation.

This new finding identifies targets for allergic diseases that could be developed into new therapeutic strategies. Professor Fallon's research on allergies is supported by Science Foundation Ireland, The Wellcome Trust, Health Research Board and National Children's Research Centre, Ireland.

Explore further: Researchers identify a target that could combat allergies of early childhood

Related Stories

'Stomach flu' may be linked to food allergies

November 14, 2011

Researchers at the Medical College of Wisconsin have found a possible link between norovirus, a virus that causes "stomach flu" in humans, and food allergies. The findings are published in The Open Immunology Journal, Volume ...

Recommended for you

Omega-3 fatty acid stops known trigger of lupus

September 29, 2016

A team of Michigan State University researchers has found that consuming an omega-3 fatty acid called DHA, or docosahexaenoic acid, can stop a known trigger of lupus and potentially other autoimmune disorders.

Resveratrol can help to reduce inflammation, study finds

September 28, 2016

A component of red wine and grapes can help control inflammation induced by a bacterial pathogen that is linked to upper respiratory tract inflammatory diseases such as asthma, chronic obstructive pulmonary diseases (COPD) ...

Quick test to detect inflammation in diabetic patients

September 27, 2016

Scientists from Nanyang Technological University, Singapore (NTU Singapore) have developed a new kit that will allow doctors to find out within minutes if diabetic patients are suffering from inflammation.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.