The effect of rosuvastatin on incident pneumonia

Statins may prevent pneumonia, according to a new study in CMAJ (Canadian Medical Association Journal). Researchers from Israel and the United States analyzed data from the JUPITER trial, a randomized, double-blind trial with placebo control groups conducted at 1315 sites in 26 countries to look at the use of the statin rosuvastatin in disease prevention. The trial involved 17 802 men aged 50 years or older and women aged 60 years or older without a history of heart disease or diabetes.

Patients were randomized to receive either a placebo or rosuvastatin, a statin used to treat high cholesterol levels and prevent heart disease. During a median follow-up period of almost two years, the researchers found that 214 people in the statin group compared with 257 people in the placebo group contracted pneumonia.

"Participants randomly assigned to receive had a modest reduction in the incidence of pneumonia compared with participants assigned to the ," writes Dr. Victor Novack, Soroka University Medical Center, Israel and coauthors.

"Although a number of observational studies have suggested a protective effect of statin use on the incidence of pneumonia and other infections, we are not aware of any evidence from prior randomized trials that specifically evaluated this question," state the authors.

The authors conclude that the "absolute risk reduction observed in this primary prevention setting was small, and the effects on infection may be greater in other settings."

More information: Paper online: www.cmaj.ca/lookup/doi/10.1503/cmaj.111017

add to favorites email to friend print save as pdf

Related Stories

Can a cholesterol drug prevent colon cancer?

Mar 22, 2011

Thomas Jefferson University has started recruiting patients for a new National Cancer Institute (NCI)-sponsored clinical trial to test whether the cholesterol-reducing drug rosuvastatin is effective in the prevention of recurrent ...

Recommended for you

Evidence-based recs issued for systemic care in psoriasis

8 hours ago

(HealthDay)—For appropriately selected patients with psoriasis, combining biologics with other systemic treatments, including phototherapy, oral medications, or other biologic, may result in greater efficacy ...

Bacteria in caramel apples kills at least four in US

8 hours ago

A listeria outbreak believed to originate from commercially packaged caramel apples has killed at least four people in the United States and sickened 28 people since November, officials said Friday.

Steroid-based treatment may answer needs of pediatric EoE patients

9 hours ago

A new formulation of oral budesonide suspension, a steroid-based treatment, is safe and effective in treating pediatric patients with eosinophilic esophagitis (EoE), according to a new study in Clinical Gastroenterology and Hepatology, the official clinical practice journal ...

Discovery of genes that predispose a severe form of COPD

11 hours ago

A study by Ramcés Falfán-Valencia, researcher at the National Institute of Respiratory Diseases (INER), found that the mestizo Mexican population has a number of variations in certain genes that predispose ...

On the environmental trail of food pathogens

12 hours ago

Tracking one of the deadliest food contamination organisms through produce farms and natural environments alike, Cornell microbiologists are showing how to use big datasets to predict where the next outbreak could start.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.