The effect of rosuvastatin on incident pneumonia

March 19, 2012

Statins may prevent pneumonia, according to a new study in CMAJ (Canadian Medical Association Journal). Researchers from Israel and the United States analyzed data from the JUPITER trial, a randomized, double-blind trial with placebo control groups conducted at 1315 sites in 26 countries to look at the use of the statin rosuvastatin in disease prevention. The trial involved 17 802 men aged 50 years or older and women aged 60 years or older without a history of heart disease or diabetes.

Patients were randomized to receive either a placebo or rosuvastatin, a statin used to treat high cholesterol levels and prevent heart disease. During a median follow-up period of almost two years, the researchers found that 214 people in the statin group compared with 257 people in the placebo group contracted pneumonia.

"Participants randomly assigned to receive had a modest reduction in the incidence of pneumonia compared with participants assigned to the ," writes Dr. Victor Novack, Soroka University Medical Center, Israel and coauthors.

"Although a number of observational studies have suggested a protective effect of statin use on the incidence of pneumonia and other infections, we are not aware of any evidence from prior randomized trials that specifically evaluated this question," state the authors.

The authors conclude that the "absolute risk reduction observed in this primary prevention setting was small, and the effects on infection may be greater in other settings."

Explore further: Intensive-dose statin therapy associated with increased risk of diabetes

More information: Paper online:

Related Stories

Recommended for you

Monkeys in Asia harbor virus from humans, other species

November 19, 2015

When it comes to spreading viruses, bats are thought to be among the worst. Now a new study of nearly 900 nonhuman primates in Bangladesh and Cambodia shows that macaques harbor more diverse astroviruses, which can cause ...

One-step test for hepatitis C virus infection developed

November 14, 2015

UC Irvine Health researchers have developed a cost-effective one-step test that screens, detects and confirms hepatitis C virus (HCV) infections. Dr. Ke-Qin Hu, director of hepatology services, will present findings at the ...

Computer model reveals deadly route of Ebola outbreak

November 10, 2015

Using a novel statistical model, a research team led by Columbia University's Mailman School of Public Health mapped the spread of the 2014-2015 Ebola outbreak in Sierra Leone, providing the most detailed picture to date ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.