Gene profile correlates with glycemia in type 1 diabetes

Gene profile correlates with glycemia in type 1 diabetes

(HealthDay) -- A gene expression profile in peripheral blood correlates with glycemic control in the first year for patients recently diagnosed with type 1 diabetes, according to a study published online March 8 in Diabetes.

Katharine M. Irvine, Ph.D., from the University of Queensland Diamantina Institute in Brisbane, Australia, and colleagues analyzed gene expression in peripheral blood monocytes in six healthy subjects and 16 children recently diagnosed (approximately three months earlier) with . Clinical features were analyzed from diagnosis to one year.

The researchers found that monocyte expression profiles from the clustered into two distinct groups that deviated either mildly or severely from healthy subjects. Compared with patients whose deviation was mild, patients whose deviation was severe had significantly higher hemoglobin A1c levels during the first year (adjusted for insulin dose). In the diabetes-associated expression signature, multiple perturbations were identified in pathways associated with and survival. An expression signature composed of nine genes correlated with glycemic control in an independent group of 12 recent-onset patients and was also present in healthy first-degree relatives.

"A peripheral blood gene expression signature correlates with glycemic control in the first year after diabetes diagnosis and is present in at-risk subjects," Irvine and colleagues conclude. "These findings implicate monocyte phenotype as a candidate biomarker for disease progression pre- and post-onset and systemic stresses as contributors to innate immune function in type 1 diabetes."

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Low-carb diets prove better at controlling type 2 diabetes

Jan 05, 2009

In a six-month comparison of low-carb diets, one that encourages eating carbohydrates with the lowest-possible rating on the glycemic index leads to greater improvement in blood sugar control, according to Duke University ...

Diabetic polyneuropathy not up with impaired glycemia

Mar 03, 2012

(HealthDay) -- Although significantly increased in subjects with new diabetes, the rates of typical diabetic polyneuropathy (DPN), retinopathy, and nephropathy are not significantly different between subjects ...

People at risk of diabetes offer clues toward novel drugs

Feb 14, 2011

Once people develop type 2 diabetes, high blood glucose levels alter their metabolism so much that it becomes difficult to sift through all the clues to find what might enable the disease. "To identify factors that play a ...

Recommended for you

Diabetes and Thanksgiving can live in harmony

Nov 25, 2014

As you may know, November is National Diabetes Month. If you, a loved one, or a Thanksgiving guest have diabetes or prediabetes, this column is dedicated to you, as you may be wondering how to enjoy one of the most food-laden ...

Does a yogurt a day keep diabetes away?

Nov 24, 2014

A high intake of yogurt has been found to be associated with a lower risk of developing type 2 diabetes, according to research published in open access journal BMC Medicine. This highlights the importance of hav ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.