Use of stem cells, conditioning induces immune tolerance
(HealthDay) -- A novel approach using a bioengineered mobilized cellular product enriched with hematopoietic stem cells (HSCs) and tolerogenic graft facilitating cells (FCs) in combination with nonmyeloablative conditioning is safe and practical for inducing immune tolerance after transplantation, according to a study published in the March 7 issue of Science Translational Medicine.
Joseph Leventhal, M.D., from Northwestern Memorial Hospital in Chicago, and colleagues tested an approach to induce immune tolerance in eight individuals, aged 29 to 56 years, receiving human leukocyte antigen-mismatched kidneys and FC/HSC transplants, who underwent conditioning with fludarabine, total body irradiation, and cyclophosphamide. After transplantation, tacrolimus and mycophenolate mofetil were used for immunosuppression.
The researchers found that, about one week following transplantation, the absolute neutrophil counts reached a nadir, with recovery by two weeks. At one month, multilineage chimerism ranged from 6 to 100 percent. There was good tolerance of the conditioning, with outpatient management after day two post-surgery. Low-dose tacrolimus monotherapy was given to two patients who exhibited transient chimerism. Two months after transplant, one individual developed viral sepsis and experienced renal artery thrombosis. Durable chimerism, immunocompetence, and donor-specific tolerance were experienced by five subjects, who were successfully weaned off all immunosuppression at one year post-transplant. Anti-donor antibodies were not produced by any of the recipients, nor did any recipient exhibit engraftment syndrome or graft-versus-host-disease.
"These results suggest that manipulation of a mobilized stem cell graft and nonmyeloablative conditioning represents a safe, practical, and reproducible means of inducing durable chimerism and donor-specific tolerance in solid organ transplant recipients," the authors write.
Several of the authors disclosed financial ties to Regenerex and/or are authors on a patent pertaining to the study.
Journal reference: Science Translational Medicine
Copyright © 2012 HealthDay. All rights reserved.
- New transplant method may allow kidney recipients to live life free of anti-rejection medication Mar 07, 2012 | not rated yet | 0
- Stem cell study seeks to wean non-related transplant recipients from anti-rejection drugs May 28, 2009 | not rated yet | 0
- 'Mini transplant' patients' outcomes similar using related and unrelated donor cells Dec 03, 2007 | not rated yet | 0
- Out of body experience for stem cells may lead to more successful transplants Aug 04, 2011 | not rated yet | 0
- Irradiation and stem cells used in new treatment to enable kidney recipients to forego immunosuppressant drugs Mar 08, 2012 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
question on coriolis effect with drag force
6 hours ago I really need help with this question. A small floating object initially moves with velocity v on the surface of a liquid at latitude λ. The...
Question of reflection and transmission of TEM wave in normal incidenc
11 hours ago Suppose TEM wave in +z normal to a boundary on xy plane at z=0. We know *E* & *H* are tangential to the boundary. Let ##\vec E_i=\hat x E##, be the...
the rudyak-krasnolutski effective potencial
12 hours ago Hi ... anyone now how to calculate or the formula of the rudyak-krasnolutski EFFECTIVE potencial ? the effective potencial includes the angular...
Normal force for a lever model
14 hours ago My model is a lever on a table top. One arm is horizontal on the table, while the other arm is raised at an angle alpha. I'm assuming the weight of...
gravity is std. therefore can we rate a 'mass at height' by watts?
19 hours ago For example.... wind turbines are primarily listed by their wattage (1.5MW etc.) Presumably their output is varied according to rotational speed, so...
Calculating on-axis elements of a solenoid
May 22, 2013 I wanted to mention that this solenoid has many winds over many layers. The thickness of the windings is 2.4 inches coming off of the engineering...
- More from Physics Forums - Classical Physics
More news stories
(Medical Xpress)—Scientists at Emory Vaccine Center have shown that an immune regulatory molecule called IL-21 is needed for long-lasting antibody responses in mice against viral infections.
Immunology 20 hours ago | 5 / 5 (1) | 0 |
Human breastmilk responds quickly to protect the child when there is an infection in mothers or babies, according to new international research led by The University of Western Australia.
Immunology 21 hours ago | 5 / 5 (1) | 0
(Medical Xpress)—A research team, led by Jeremy Barr, a biology post-doctoral fellow, unveils a new immune system that protects humans and animals from infection.
Immunology May 20, 2013 | 4.8 / 5 (26) | 8 |
(Medical Xpress)—Scientists at King's College London have discovered that Vitamin D has the potential to significantly reduce the symptoms of asthma. The study, led by Professor Catherine Hawrylowicz from ...
Immunology May 20, 2013 | 5 / 5 (1) | 0 |
The British Menopause Society and Women's Health Concern have today released updated guidelines on Hormone Replacement Therapy (HRT) to provide clarity around the role of HRT, the benefits and the risks. The new guidelines ...
2 minutes ago | not rated yet | 0
(Medical Xpress)—Regulating the distribution of power in neurons is done by a system that makes the national electric grid look simple by comparison. Each neuron has several thousand mitochondria confined ...
11 hours ago | 4.8 / 5 (6) | 0 |
A brief visual task can predict IQ, according to a new study. This surprisingly simple exercise measures the brain's unconscious ability to filter out visual movement. The study shows that individuals whose ...
16 hours ago | 4.5 / 5 (10) | 1 |
Teams of highly respected Alzheimer's researchers failed to replicate what appeared to be breakthrough results for the treatment of this brain disease when they were published last year in the journal Science.
14 hours ago | 5 / 5 (1) | 2 |
Scientists at the National Institutes of Health report they have discovered in mouse studies that a small molecule released in the spinal cord triggers a process that is later experienced in the brain as ...
14 hours ago | 5 / 5 (2) | 0 |
Little is known about why asthma develops, how it constricts the airway or why response to treatments varies between patients. Now, a team of researchers at Weill Cornell Medical College, Columbia University Medical Center ...
15 hours ago | not rated yet | 0 |