Antimicrobial resistance for common urinary tract infections drug increases five fold since 2000

WASHINGTON, District of Columbia (April 30, 2012) – In a surveillance study of over 12 million bacteria, investigators at The George Washington University and Providence Hospital found E. coli antimicrobial resistance to ciprofloxacin, the most commonly prescribed antimicrobial for urinary tract infections in the U.S., increased over five-fold from 2000 to 2010. In addition, nearly one in four isolates in 2010 were resistant to trimethoprim-sulfamethoxazole (Bactrim®), the second most commonly prescribed drug for this infection. This research was published in the April edition of the journal, Antimicrobial Agents and Chemotherapy.

"Our study is important because it shows that E. coli resistance to two common drugs to treat UTIs rose substantially over the last decade. For patients, this will ultimately translate into more expensive and sometimes more complex antimicrobial treatments. What is more concerning however, is the lack of new antimicrobial development which has been declining for decades," said Guillermo Sanchez, a graduate student in the Physician Assistant program at the George Washington University and primary author of the study.

E. coli accounts for 75% to 95% of infections (UTIs) and UTIs are among the most common infections in humans, with half of all women experiencing at least one in their lifetime. E. coli is a major factor in determining health outcomes in patients with UTIs. E. coli antimicrobial resistance has been associated with lower likelihood of clinical cure and increased risk of infection recurrence. Additionally, antimicrobial resistance significantly increases patient morbidity, costs of treatment, and rates of hospitalization.

As antimicrobial resistance continues to increase, remaining antimicrobial drug options have a higher likelihood of causing unwanted side effects such as gastrointestinal distress, nausea, and vomiting. Due to a lack of drug development, the paucity of new antimicrobial drugs for common infections like UTIs will continue to worsen in the near future.

"Our study reveals that ciprofloxacin and TMP-SMX are not longer safe for outpatient urinary tract infection (UTI). Our study indicates that safer antimicrobials for outpatient UTI are nitrofurantoin in patients without kidney insufficiency and amoxicillin/clavulanate and third generation cephalosporins for all others", said Jose Bordon, MD Ph.D., AAHIVS, Infectious Disease Specialist at Providence Hospital in Washington, DC.

add to favorites email to friend print save as pdf

Related Stories

Antimicrobial catheters could save NHS millions

Mar 27, 2012

A new catheter coating that reduces bacterial attachment to its surface is being developed by scientists who are reporting their work at the Society for General Microbiology's Spring Conference in Dublin this ...

Urinary tract infections linked to contaminated chicken

Feb 20, 2012

Urinary tract infections are common conditions that occur when bacteria from the intestines enter the urinary tract. New research, however, suggests that the bacteria causing these infections may come from contaminated food ...

'Resuscitating' antibiotics to overcome drug resistance

Mar 28, 2012

Combining common antibiotics with additional compounds could make previously resistant bacteria more susceptible to the same antibiotics. 'Resuscitation' of existing antibiotics has the potential to make infections caused ...

Recommended for you

Nanopatch to help WHO battle polio

2 hours ago

The World Health Organisation's (WHO) battle against polio has a new weapon after joining forces with Vaxxas, the biotechnology company responsible for developing revolutionary vaccine delivery method the Nanopatch.

Obama's Ebola response: Is it enough and in time?

6 hours ago

President Barack Obama declared Tuesday that the Ebola epidemic in West Africa could threaten security around the world, and he ordered 3,000 U.S. military personnel to the region in emergency aid muscle ...

First domestic case of chikungunya in Brazil

6 hours ago

Brazil's authorities on Tuesday reported the first domestically contracted cases of the mosquito-borne chikungunya virus, prompting the government to announce it was stepping up attempts to control the disease.

Australia promises $6.4 million to fight Ebola

7 hours ago

Australia announced on Wednesday it will immediately provide an additional 7 million Australian dollars ($6.4 million) to help the international response to the Ebola outbreak in West Africa.

User comments