CV autonomic neuropathy risk for CVD despite albumin status

CV autonomic neuropathy risk for CVD despite albumin status
Cardiovascular autonomic neuropathy appears to affect the risk of cardiovascular disease even in type 1 diabetes patients with normal albumin excretion rates, according to a study published online April 12 in Diabetes.

(HealthDay) -- Cardiovascular autonomic neuropathy (CAN) appears to affect the risk of cardiovascular disease even in type 1 diabetes patients with normal albumin excretion rates, according to a study published online April 12 in Diabetes.

Noting that CAN is present in about a quarter of patients with type 1 diabetes, Ulrik Madvig Mogensen, M.D., from the University Hospital of Copenhagen in Denmark, and colleagues measured coronary artery plaque burden, coronary artery calcium, left ventricular function, and blood pressure and pulse pressure over a 24-hour period in 56 normoalbuminuric type 1 , 26 of whom had CAN.

The researchers found that, compared with patients without CAN, patients with CAN had higher coronary artery calcium scores. For patients with CAN, a nonsignificant trend was noted toward higher prevalence of coronary plaques and flow-limiting stenosis. After controlling for various factors, there was an independent association between CAN and higher scores, subtle impairment of left ventricular systolic and , and higher pulse pressure.

"In conclusion, CAN in normoalbuminuric type 1 diabetic patients is associated with distinct signs of subclinical cardiovascular disease," Mogensen and colleagues conclude.

One author was supported by a scholarship from .

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

High blood sugar lowers chances of surviving a heart attack

Mar 26, 2012

Patients with high blood sugar run an increased risk of dying if they have a heart attack, and diabetics are less likely to survive in-hospital cardiac arrest than non-diabetics, reveals research at the Sahlgrenska Academy, ...

Recommended for you

Time to take notice and tackle heart failure

18 minutes ago

Experts have sounded a call to action for policy makers at local, national, and international levels to promote heart failure prevention, improve heart failure awareness among healthcare professionals, ensure ...

Hopes dashed for an agent to prevent reperfusion injury

3 hours ago

The administration of an experimental agent known as TRO40303 to patients who have had a heart attack, with the hope of preventing tissue damage when impaired blood flow is corrected (reperfusion), was disappointingly ineffective ...

User comments