New study challenges current thinking on risk factors for contrast induced nephrotoxicity

Contrary to current belief, a new study finds that patients with a history of diabetes are not one of the most at risk for contrast induced nephrotoxicity. Instead, the study found that patients with a history of renal disease, hypertension and/or heart disease are more likely to suffer from renal insufficiency, putting them at greater risk for contrast induced nephrotoxicity.

The study, done at Northwestern Memorial Hospital-Northwestern University in Chicago, included 2,404 patients. All patients underwent an estimated (eGFR) test immediately before undergoing a CT examination. "Since all patients underwent the eGFR test, we had an unusual opportunity to see if the traditional risk factors truly predict reduced renal function, said Vahid Yaghmai, MD, one of the authors of the study.

The study found that "patients with history of renal disease, hypertension and heart disease had significantly higher odds of having abnormal eGFR," said Dr. Yaghmai. That was not the case for patients with diabetes, he said.

Many facilities ask patients to fill out a survey to help determine if the patients are at risk for contrast induced nephropathy, said Dr. Yaghmai. Based on the survey results, patients most at risk undergo a test to measure their renal function. "Measuring eGFR right before the CT scan can help us more accurately determine at-risk patients. Our results suggest that history of diabetes is not independent predictors of having reduced ," noted Dr. Yaghmai.

The study will be presented May 1, during the 2012 ARRS Annual Meeting in Vancouver, Canada.

add to favorites email to friend print save as pdf

Related Stories

Can eGFR be a routine preoperative renal function test?

May 20, 2010

A research team from Japan evaluated the validity of the estimated glomerular filtration rate (eGFR) as a preoperative renal function parameter in patients with gastric cancer. Their study showed that eGFR was as equally ...

Lower contrast agent dose feasible in 320 row CT angiography

Oct 01, 2011

The analysis of 180 CT angiography studies done using a 320 detector row CT scanner found that a contrast media protocol based on 60 milliliters of iopamidol "had sufficient enhancement in more than 96% of coronary segments," ...

Test predicts who will develop end-stage renal disease

Apr 08, 2009

Measuring kidney function by assessing two different factors—glomerular filtration rate (GFR) and urinary albumin levels—helps determine which patients with chronic kidney disease (CKD) will develop end-stage renal disease ...

Recommended for you

Ebola in mind, US colleges screen some students

7 hours ago

University students from West Africa may be subject to extra health checks when they arrive to study in the United States as administrators try to insulate their campuses from the worst Ebola outbreak in ...

WHO: More Ebola cases in past week than any other

8 hours ago

The past week has seen the highest increase of Ebola cases since the outbreak in West Africa began, the World Health Organization said Friday, offering more evidence that the crisis is worsening.

User comments