Light dynamics for cancer treatment

May 3, 2012

Research is delving into refinement of a revolutionary cancer treatment, photodynamic therapy (PDT). Using light, reactive oxygen and photosensitisers linked to specially designed antibodies, scientists are on the threshold of a highly specific cancer therapy.

PDT is an ingenious treatment using a drug – a photosensitiser – that absorbs light of a certain wavelength thereby inducing production of reactive that in turn kills nearby cells. Specially designed photosensitisers are absorbed by all cells in the body but stay in cells longer. This means that reactive oxygen destroys cancer cells selectively when they are exposed to the appropriate light wavelength.

The therapy is suitable for the removal of superficial neoplastic tumours in areas like the head and neck as well as urogenital and gynaecological systems that are inoperable. As the wavelength of the light determines how far the light travels into the body, the technique in principle has huge potential in that only destroys tumour and not healthy cells.

An EU-funded project 'Immunophotodynamic therapy of cancer: concepts and applications' (Immuno PDT) aimed to further improve the efficacy of PDT by developing novel photosensitisers that absorb light in the infrared range where light penetration of tissues is maximal. Furthermore, the Immuno PDT team targeted tumour neo-vasculature to close tumour blood vessels thereby destroying many tumour cells dependent on blood supply.

Immuno PDT made substantial progress in the development of antibody-based photosensitiser conjugates made up of the photosensitiser bound to an antibody. The researchers synthesised photosensitive molecules that do not stick to unwanted cells and tissues. Novel human antibodies were also isolated for corresponding tumour- associated antigens.

Dependent on the antibody and photosensitiser efficiently joining together, Immuno PDT successfully investigated a new method of conjugation. Novel PDT agents have been extensively tested in vitro and in rat models. At close of the project, three of the new were being manufactured for potential clinical use and eight patent applications had been submitted.

Apart from the applications in therapy for otherwise inoperable tumours, there is considerable scope for other treatments under the umbrella of immunotherapy. These include biological treatments for cancers using the body's immune system to fight tumours.

Explore further: UV light improving chances of fighting cancer

Related Stories

UV light improving chances of fighting cancer

October 30, 2007

Scientists at Newcastle University have developed a cancer fighting technology which uses UV light to activate antibodies which very specifically attack tumours.

New targeted approach to light-activated cancer drugs

November 8, 2007

Combining light-activated cancer drugs with tumour-seeking antibodies could provide a more effective way of treating many cancers, according to new research published in advance online in the International Journal of Cancer.

Recommended for you

Oxygen can impair cancer immunotherapy in mice

August 25, 2016

Researchers have identified a mechanism in mice by which anticancer immune responses are inhibited within the lungs, a common site of metastasis for many cancers. This mechanism involves oxygen inhibition of the anticancer ...

Stem cell propagation fuels cancer risk in different organs

August 25, 2016

The idea that stem cells - special cells that divide to repair and generate tissues - might be the major determinant of cancer risk has provoked great debate in the scientific community. Some researchers maintain that environmental ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.