Exploring cancer with computers
(Medical Xpress) -- Computers can be used to identify cancer treatment targets that wouldn't otherwise have been considered, according to research by an Australian team.
Professor Mark Ragan from The University of Queensland's Institute for Molecular Bioscience (IMB), who led the research team, says they found that computational methods could be used to untangle the intricacies of cancer biology.
“Cancer is not a disease caused by single genes. Rather, it is changes to the underlying gene regulatory networks that prompt tumours to grow and spread,” he said.
“Understanding gene regulatory networks in healthy and diseased tissues is therefore critical to devising effective cancer treatments.
“These networks involve vast numbers of interactions between different molecules, making conventional experimental approaches, which are focused on individual genes, too time-consuming,” he said.
The findings came from the team's analysis of different computational methods of studying gene regulatory networks.
By contrast, computational methods can examine complex networks of interacting molecules across entire systems. The challenge for researchers is determining the accuracy of such methods.
The IMB team undertook a thorough analysis of nine different computational methods that represented a variety of approaches. They then took the method judged most effective and applied it to real ovarian cancer data.
“Our evaluation demonstrated that it's possible in some cases to use computational methods to gain insights into cancer biology.
“These methods can pinpoint targets that wouldn't otherwise have been considered, which can then be validated with laboratory experiments.”
The findings are published in the current edition of the scientific journal Genome Medicine, where it has been nominated as part of the thematic series Cancer bioinformatics: bioinformatic methods, network biomarkers and precision medicine.
Provided by University of Queensland
- Personalising the use of chemotherapy in breast cancer treatment Dec 15, 2011 | not rated yet | 0
- The largest known true crocodile identified May 05, 2012 | not rated yet | 0
- Sandia paper on flat-panel displays is one of Applied Physics Letters' 50 greatest hits May 07, 2012 | not rated yet | 0
- New microfluidic device could be used to diagnose and monitor cancer and other diseases Feb 22, 2012 | not rated yet | 0
- CMS in 2011: A mountain of particle collision data Jan 17, 2012 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Why is zone 1 in liver more prone to ischemic injury?
May 23, 2013 Hi, Is it because around central vein, there is only deoxygenated blood from the vein where as in the periphery there is hepatic artery. Also why...
How can there be villous adenoma in colon, if there are no villi there
May 22, 2013 As title suggest. Thanks :smile:
How can there be a term called "intestinal metaplasia" of stomach
May 21, 2013 Hello everyone, Ok Stomach's normal epithelium is simple columnar, now in intestinal type of adenocarcinoma of stomach it undergoes "intestinal...
Pressure-volume curve: Elastic Recoil Pressure don't make sense
May 18, 2013 From pressure-volume curve of the lung and chest wall (attached photo), I don't understand why would the elastic recoil pressure of the lung is...
If you became brain-dead, would you want them to pull the plug?
May 17, 2013 I'd want the rest of me to stay alive. Sure it's a lousy way to live but it beats being all-the-way dead. Maybe if I make it 20 years they'll...
MRI bill question
May 15, 2013 Dear PFers, The hospital gave us a $12k bill for one MRI (head with contrast). The people I talked to at the hospital tell me that they do not...
- More from Physics Forums - Medical Sciences
More news stories
In recent years, microRNAs (miRNAs) and other non-coding RNAs are small molecules that help control the expression of specific proteins. In recent years they have emerged as disease biomarkers. miRNA profiles have been used ...
Cancer May 24, 2013 | not rated yet | 0
Cancer cells spread and grow by avoiding detection and destruction by the immune system. Stimulation of the immune system can help to eliminate cancer cells; however, there are many factors that cause the immune system to ...
Cancer May 24, 2013 | 5 / 5 (1) | 0
Researchers from London's Kingston University have begun a two-year study which could help prolong the lives of people with colorectal tumours.
Cancer May 24, 2013 | 5 / 5 (1) | 0
Transformative research from Western University has identified new hormones in the body which may suppress breast cancer and stimulate the regression of breast tumors.
Cancer May 24, 2013 | 5 / 5 (2) | 0
(Medical Xpress)—Curtin University researchers have found evidence that targeting specific cells in the body can reverse the effects of cancer on the immune system.
Cancer May 24, 2013 | 5 / 5 (4) | 0
Coenzyme Q10 decreases all cause mortality by half, according to the results of a multicentre randomised double blind trial presented today at Heart Failure 2013 congress. It is the first drug to improve heart failure mortality ...
20 hours ago | 5 / 5 (6) | 5
Heart failure accelerates the aging process and brings on early andropausal syndrome (AS), according to research presented today at the Heart Failure Congress 2013. AS, also referred to as male 'menopause', was four times ...
20 hours ago | 5 / 5 (1) | 1
(HealthDay)—Animals make great companions for senior citizens, but elderly people who always drive with a pet in the car are far more likely to crash than those who never drive with a pet, researchers have ...
12 hours ago | not rated yet | 1
(Medical Xpress)—A research team, led by Jeremy Barr, a biology post-doctoral fellow, unveils a new immune system that protects humans and animals from infection.
May 20, 2013 | 4.8 / 5 (31) | 9 |
Until now, little was scientifically known about the human potential to cultivate compassion—the emotional state of caring for people who are suffering in a way that motivates altruistic behavior.
May 22, 2013 | 4.3 / 5 (6) | 6 |
Mortality and length of stay are highest in heart failure patients admitted in January, on Friday, and overnight, according to research presented today at the Heart Failure Congress 2013. The analysis of nearly 1 million ...
20 hours ago | not rated yet | 0