Experts say protocols for identifying endocrine-disrupting chemicals inadequate
In a Statement of Principles unveiled today, The Endocrine Society proposes a streamlined definition for endocrine-disrupting chemicals (EDCs) and offers recommendations that will strengthen the ability of current screening programs to identify EDCs.
An endocrine-disrupting chemical (EDC) is a chemical or mixture of chemicals in the environment, that can interfere with any aspect of hormone action. The Endocrine Society's Scientific Statement published in 2009 provided an exhaustive summary of the scientific background that justifies concern for the effects of EDC exposures to humans and wildlife.
"Because of the interest and expertise of our members, The Endocrine Society is in a unique position to help inform the ongoing debate about the health effects of endocrine disruptors," said R. Thomas Zoeller, PhD, of the University of Massachusetts and lead author of the statement. "The new statement outlines key issues related to identifying EDCs and protecting humans and wildlife from their adverse effects."
The current statement addresses the importance of having an accurate definition for endocrine-disrupting chemicals. The definition is critical because it dictates the evidence required to identify a chemical as an EDC and informs the subsequent steps of assessing the risk of EDC exposures.
In the statement the Society proposes an EDC be defined as an exogenous chemical, or mixture of chemicals, that interferes with any aspect of hormone action. This definition purposefully omits reference to adverse effects, as there is lack of agreement on what constitutes an adverse effect. According to the statement, the ability of a chemical to interfere with hormone action is a clear predictor of adverse outcome if exposure occurs during critical periods or developmental processes.
Recommendations in the statement include:
- Basic scientists actively engaged in the development of new knowledge in relevant disciplines should be involved in evaluating the weight-of-evidence of EDC studies, as well as in the design and interpretation of studies that inform the regulation of EDCs;
- State-of-the-art molecular and cellular techniques, and highly sensitive model systems, need to be built into current testing, in consultation with the appropriate system experts;
- Testing needs to include models of developmental exposure during critical life periods when organisms may be most vulnerable to even very low-dose exposures;
- The design and interpretation of tests must incorporate the biological principle that EDCs act through multiple mechanisms in physiological systems; and
- Endocrine principles, such as those outlined in this document, should be incorporated into programs by the U.S. Environmental Protection Agency (EPA) and other agencies charged with evaluating chemicals for endocrine-disrupting potential.
- Environmental chemicals that interfere with any aspect of hormone action should be presumed to produce adverse effects;
- EDC exposures during development can have effects on hormone action that cannot be corrected, leaving permanent adverse impacts on cognitive function and other health parameters;
- People are exposed to multiple EDCs at the same time, and these mixtures can have a greater effect on the hormone system than any single EDC alone; and
- The weight-of-evidence guidance developed by the EPA must be strengthened by adhering to principles of endocrinology outlined here, including low-dose effects and nonlinear or nonmonotonic dose-response curves.
More information: The statement, "Endocrine-Disrupting Chemicals and Public Health Protection: A Statement of Principles from The Endocrine Society," appears in the September 2012 issue of Endocrinology.
Provided by The Endocrine Society
- Current chemical testing missing low-dosage effects of endocrine-disrupting chemicals Mar 29, 2012 | not rated yet | 0
- Endocrine-disrupting chemicals pose cancer risk May 25, 2010 | not rated yet | 0
- Prenatal exposure to endocrine-disrupting chemicals linked to breast cancer May 21, 2010 | not rated yet | 0
- Simpler lifestyle found to reduce exposure to endocrine-disrupting chemicals Jun 26, 2012 | not rated yet | 0
- Research proves 'gender-bending' chemicals affect reproduction Oct 26, 2010 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Classical and Quantum Mechanics via Lie algebras
Apr 15, 2011 I'd like to open a discussion thread for version 2 of the draft of my book ''Classical and Quantum Mechanics via Lie algebras'', available online at http://lanl.arxiv.org/abs/0810.1019 , and for the...
- More from Physics Forums - Independent Research
More news stories
Talking on a hands-free device while behind the wheel can lead to a sharp increase in errors that could imperil other drivers on the road, according to new research from the University of Alberta.
Health 6 hours ago | not rated yet | 0
(HealthDay)—More than one in four of those eligible for new premium assistance tax credits under the Affordable Care Act (ACA) do not have a checking account and will not be able to receive premiums from ...
Health 8 hours ago | not rated yet | 0
After studying noise in one French Quarter neighborhood of New Orleans to determine whether or not noise levels exceeded municipal ordinances, Annette Hurley, PhD, Assistant Professor of Audiology at LSU Health Sciences Center ...
Health 10 hours ago | not rated yet | 0
Young children who missed more than half of recommended well-child visits had up to twice the risk of hospitalization compared to children who attended most of their visits, according to a study published today in the American Jo ...
Health 10 hours ago | not rated yet | 0
The individualisation of drug treatments to support patients to self-manage their conditions is a concept that sits at the heart of policy, but a recent study in BMJ Open shows that there is no concrete defini ...
Health 12 hours ago | 3 / 5 (1) | 0
(Medical Xpress)—A new study by researchers in the US has shown that an ancient virus can be modified to help in the fight against the simian immunodeficiency virus SIV, which is the equivalent in monkeys ...
12 hours ago | 5 / 5 (3) | 0 |
Two mutations central to the development of infantile myofibromatosis (IM)—a disorder characterized by multiple tumors involving the skin, bone, and soft tissue—may provide new therapeutic targets, according to researchers ...
7 hours ago | 5 / 5 (1) | 0 |
Women at a particular stage in their monthly menstrual cycle may be more vulnerable to some of the psychological side-effects associated with stressful experiences, according to a study from UCL.
9 hours ago | 5 / 5 (2) | 0 |
Biological processes are generally based on events at the molecular and cellular level. To understand what happens in the course of infections, diseases or normal bodily functions, scientists would need to ...
10 hours ago | 5 / 5 (2) | 0 |
(HealthDay)—Comorbid conditions often accompany alopecia areata, according to a study published online May 22 in JAMA Dermatology.
8 hours ago | not rated yet | 0
Kate O'Reilly's spring allergy survival kit includes the usual stuff - nasal sprays, allergy pills and a box of tissues. This season, she's added a new weapon to her line of defense: an app on her smartphone.
7 hours ago | not rated yet | 0