Newborn screening may miss adrenal-gland disorder

Newborn screening may miss adrenal-Gland disorder
Review of Minnesota records finds 22 percent error rate.

(HealthDay) -- Routine newborn screening failed to identify about one-fifth of infants with an adrenal gland disorder called congenital adrenal hyperplasia, a new study has found.

This genetic disorder is characterized by a deficiency of the hormones aldosterone and cortisol, and overproduction of (androgens). The effects can range from mild to severe.

In the study, researchers looked at data on more than 800,000 newborns who underwent in Minnesota between 1999 and 2010. Of those newborns, 52 with were identified and 15 -- 22 percent -- with the disorder were missed.

The study found that a negative screening result does not definitively rule out the condition, the researchers said.

"Screening programs should educate clinicians about false-negative results so any patient for whom there is clinical concern for [congenital adrenal hyperplasia] can receive immediate diagnostic testing, particularly females with ambiguous genitalia," said Dr. Kyriakie Sarafoglou, of the University of Minnesota Amplatz Children's Hospital in Minneapolis.

The study appears June 13 in the .

More information: The U.S. National Institute of Child Health and Human Development has more about congenital adrenal hyperplasia.

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Senegal monitors contacts of 1st Ebola patient

8 hours ago

Senegalese authorities on Monday were monitoring everyone who was in contact with a student infected with Ebola who crossed into the country, and who has lost three family members to the disease.

Cerebral palsy may be hereditary

14 hours ago

Cerebral palsy is a neurological developmental disorder which follows an injury to the immature brain before, during or after birth. The resulting condition affects the child's ability to move and in some ...

19 new dengue cases in Japan, linked to Tokyo park

20 hours ago

Japan is urging local authorities to be on the lookout for further outbreaks of dengue fever, after confirming another 19 cases that were contracted at a popular local park in downtown Tokyo.

User comments