Automated variation measure indicates risk of breast cancer
A variation measure, estimated from an automated algorithm of the grayscale variation within a mammogram, correlates with the risk of breast cancer as strongly or more so than percent density, according to a study published online July 3 in the Journal of the National Cancer Institute.
(HealthDay) -- A variation measure, estimated from an automated algorithm of the grayscale variation within a mammogram, correlates with the risk of breast cancer as strongly or more so than percent density (PD), according to a study published online July 3 in the Journal of the National Cancer Institute.
John J. Heine, Ph.D., from the H. Lee Moffitt Cancer Center & Research Institute in Tampa, Fla., and colleagues developed an automated, objective measure of grayscale value variation within a mammogram, examined its correlation with breast cancer, and compared its performance with PD. Data were utilized from three studies: a case-cohort study involving 217 cases and 2,094 non-case individuals, and two case-control studies involving 928 and 246 cases matched with 1,039 and 516 controls, respectively.
The researchers found that, in all three studies, the variation measure correlated significantly with the risk of breast cancer (highest versus lowest quartile: hazard ratio, 7.0; odds ratio, 10.7; odds ratio, 2.6; all Ptrend < 0.001). The risk estimates and area under the receiver operating characteristic curves were greater for the variation measure than PD in two studies (0.71 and 0.76 versus 0.65 and 0.65); in the third study the estimates were similar (0.60 and 0.61). In a meta-analysis of the three studies there was a stronger correlation observed between variation and breast cancer than PD and breast cancer (highest versus lowest quartile: relative risk, 3.6 and 2.3, respectively).
"These results suggest that the variation measure is a viable automated mammographic density measure that is consistent across film and digital imaging platforms and may be useful in the clinical setting for risk assessment," the authors write.
More information: Abstract
Full Text (subscription or payment may be required)
Journal reference:
Journal of the National Cancer Institute
Copyright © 2012 HealthDay. All rights reserved.
-
Vitamin D influences racial differences in breast cancer risk
Apr 04, 2012 |
not rated yet |
0
-
Breast density linked to increased risk of subsequent breast cancer
Oct 07, 2010 |
not rated yet |
0
-
Dense breasts can nearly double the risk of breast cancer recurrence
Mar 21, 2012 |
not rated yet |
0
-
In Taiwan, diabetes linked to increased Parkinson's risk
Apr 02, 2012 |
not rated yet |
0
-
DNA methylation level is marker of breast cancer risk
May 11, 2012 |
not rated yet |
0
-
Motion perception revisited: High Phi effect challenges established motion perception assumptions
Apr 23, 2013 |
3 / 5 (2) |
2
-
Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update)
Apr 02, 2013 |
4.5 / 5 (11) |
5
-
The visual system as economist: Neural resource allocation in visual adaptation
Mar 30, 2013 |
5 / 5 (2) |
9
-
Separate lives: Neuronal and organismal lifespans decoupled
Mar 27, 2013 |
4.9 / 5 (8) |
0
-
Sizing things up: The evolutionary neurobiology of scale invariance
Feb 28, 2013 |
4.8 / 5 (10) |
14
-
Pressure-volume curve: Elastic Recoil Pressure don't make sense
May 18, 2013
-
If you became brain-dead, would you want them to pull the plug?
May 17, 2013
-
MRI bill question
May 15, 2013
-
Ratio of Hydrogen of Oxygen in Dessicated Animal Protein
May 13, 2013
-
Alcohol and acetaminophen
May 13, 2013
-
Marie Curie's leukemia
May 13, 2013
- More from Physics Forums - Medical Sciences
More news stories
Older prostate cancer patients should think twice before undergoing treatment
Older prostate cancer patients with other underlying health conditions should think twice before committing to surgery or radiation therapy for their cancer, according to a multicenter study led by researchers in the UCLA ...
Cancer
5 hours ago |
not rated yet |
0
|
Two radiotherapy treatments show similar morbidity, cancer control after prostatectomy
Intensity-modulated radiation therapy has become the most commonly used type of radiation in prostate cancer, but research from the University of North Carolina suggests that the therapy may not be more effective than older, ...
Cancer
7 hours ago |
not rated yet |
0
The compound in the Mediterranean diet that makes cancer cells 'mortal'
New research suggests that a compound abundant in the Mediterranean diet takes away cancer cells' "superpower" to escape death. By altering a very specific step in gene regulation, this compound essentially re-educates cancer ...
Cancer
7 hours ago |
4.8 / 5 (8) |
1
|
CT radiation risk less than risk of examination indicator
(HealthDay)—For young adults needing either a chest or abdominopelvic computed tomography (CT), the short-term risk of death from underlying morbidity is greater than the long-term risk of radiation-induced ...
Cancer
8 hours ago |
not rated yet |
0
Team finds mechanism linking key inflammatory marker to cancer
In a new study described in the journal Oncogene, researchers reveal how a key player in cell growth, immunity and the inflammatory response can be transformed into a primary contributor to tumor growth.
Cancer
14 hours ago |
not rated yet |
0
|
Do salamanders hold the solution to regeneration?
Salamanders' immune systems are key to their remarkable ability to regrow limbs, and could also underpin their ability to regenerate spinal cords, brain tissue and even parts of their hearts, scientists have ...
Scientists identify molecular trigger for Alzheimer's disease
Researchers have pinpointed a catalytic trigger for the onset of Alzheimer's disease – when the fundamental structure of a protein molecule changes to cause a chain reaction that leads to the death of neurons ...
Practice makes perfect? Not so much
Turns out, that old "practice makes perfect" adage may be overblown. New research led by Michigan State University's Zach Hambrick finds that a copious amount of practice is not enough to explain why people ...
New test better detects elephantiasis worm infection
A new diagnostic test for a worm infection that can lead to severe enlargement and deformities of the legs and genitals is far more sensitive than the currently used test, according to results of a field ...
Researchers develop model for better testing, targeting of malignant peripheral nerve sheath tumors
University of Minnesota Medical School researchers from the Masonic Cancer Center, University of Minnesota, in partnership with the University's Brain Tumor Program, have developed a new mouse model of malignant peripheral ...
New immune system discovered
(Medical Xpress)—A research team, led by Jeremy Barr, a biology post-doctoral fellow, unveils a new immune system that protects humans and animals from infection.