Gastrointestinal perforation rare in rheumatoid arthritis

July 8, 2012
Gastrointestinal perforation rare in rheumatoid arthritis
Gastrointestinal perforation is a rare but serious condition that affects patients with rheumatoid arthritis, most frequently in the lower gastrointestinal tract, according to a study published online June 21 in Arthritis Care & Research.

(HealthDay) -- Gastrointestinal (GI) perforation is a rare but serious condition that affects patients with rheumatoid arthritis (RA), most frequently in the lower GI tract, according to a study published online June 21 in Arthritis Care & Research.

Jeffrey R. Curtis, M.D., M.P.H., from the University of Alabama at Birmingham, and colleagues analyzed health insurance claims data to identify the incidence and risk factors for GI perforation among 143,433 RA patients.

Using a maximally sensitive definition for GI perforation, the researchers identified 696 hospitalizations with perforation, representing a rate of 1.70 per 1,000 person-years, which was lower when a more specific definition was used (0.87 per 1,000 person years). Eighty-three percent of perforations occurred in the lower . Age and diverticulitis were the strongest risk factors for perforation (hazard ratios for diverticulitis: 14.5 for the more sensitive definition and 3.9 for the more specific definition). The risk of GI perforation was highest among patients with exposure to concomitant non-biologic disease-modifying antirheumatic drugs and glucocorticoids, compared to methotrexate. Use of biologics without glucocorticoids was not a risk factor.

"Clinicians should be aware of risk factors for GI when managing RA patients, including age, history of diverticulitis, and use of glucocorticoids or nonsteroidal anti-inflammatory drugs," the authors write.

Several authors disclosed financial ties to pharmaceutical companies; one author is an employee of Genentech.

Explore further: Childhood cancer survivors are at increased risk for ongoing post-therapy GI complications

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Lower GI problems plague many with rheumatoid arthritis

April 3, 2012

Add lower gastrointestinal (GI) problems such as ulcers, bleeding and perforations to the list of serious complications facing many rheumatoid arthritis patients. They are at greater risk for GI problems and gastrointestinal-related ...

Gender, BMI impact bladder perforation during resection

April 17, 2012

(HealthDay) -- For patients with bladder tumors, female gender, low body mass index, and tumor characteristics correlate with the risk of bladder perforation during transurethral resection, according to research published ...

Recommended for you

Team finds gene that confirms existence of psoriatic arthritis

February 5, 2015

PsA is a common form of inflammatory form of arthritis causing pain and stiffness in joints and tendons that can lead to joint damage. Nearly all patients with PsA also have skin psoriasis and, in many cases, the skin disease ...

Blocking one receptor could halt rheumatoid arthritis

September 10, 2014

Researchers at the University of Illinois at Chicago College of Medicine have shown for the first time how the activation of a receptor provokes the inflammation and bone degradation of rheumatoid arthritis—and that activation ...

Low back pain? Don't blame the weather

July 10, 2014

Australian researchers reveal that sudden, acute episodes of low back pain are not linked to weather conditions such as temperature, humidity, air pressure, wind direction and precipitation. Findings published in Arthritis ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.