Rat study shows chrysotile asbestos is strong carcinogen

Rat study shows chrysotile asbestos is strong carcinogen
Chrysotile, a commercially used type of asbestos, induces malignant mesothelioma in the rat peritoneal cavity, with pathogenesis strongly linked to iron overload, according to a study published online Aug. 2 in The Journal of Pathology.

(HealthDay) -- Chrysotile, a commercially used type of asbestos, induces malignant mesothelioma (MM) in the rat peritoneal cavity, with pathogenesis strongly linked to iron overload, according to a study published online Aug. 2 in The Journal of Pathology.

To examine the carcinogenicity of chrysotile, Li Jiang, from the Nagoya University Graduate School of Medicine in Japan, and colleagues injected rats with a suspension of standard asbestos in saline. Some of the asbestos-treated rats were injected with 80 mg/kg nitrilotriacetate (NTA) to enhance an iron-catalyzed Fenton reaction. Rat samples were analyzed for histological and immunohistochemical characteristics.

The researchers found that the pathogenesis of chrysotile-induced mesothelial carcinogenesis correlated closely with iron overload. The period required for carcinogenesis was significantly reduced with repeated administration of the iron chelator NTA. Peritoneal organs were found to have massive iron deposition. The most frequent genomic alteration in human MM and in iron-induced rodent carcinogenesis -- homozygous deletion of the CDKN2A/2B/ARF -- was observed in 92.6 percent of the cases studied with array-based comparative genomic hybridization. There was high expression of mesoderm specific transcription factors Dlx5 and Hand1 in induced rat MM cells, which demonstrated active iron uptake and utilization.

"In conclusion, chrysotile is a strong carcinogen that acts through the induction of local iron overload in vivo when it [reaches] mesothelial cells," the authors write. "Therefore, more appropriate measures have to be taken to reduce environmental cancer risk in this era of ."

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

MRI: An accurate method to evaluate iron overload

date Jan 31, 2011

A research team from Iran investigated the accuracy of T2*-weighted magnetic resonance imaging (MRI T2*) in the evaluation of iron overload in beta-thalassemia major patients. The study showed that MRI T2* is a non-invasive, ...

Europe's most common genetic disease is a liver disorder

date Feb 06, 2008

Much less widely known than the dangerous consequences of iron deficiencies is the fact that too much iron can also cause problems. The exact origin of the genetic iron overload disorder hereditary hemochromatosis (HH) has ...

Recommended for you

Researchers learn to measure aging process in young adults

date 14 hours ago

Looking around at a 20th high school reunion, you might notice something puzzling about your classmates. Although they were all born within months of each other, these 38-year-olds appear to be aging at different ...

New paradigm for treating 'inflammaging' and cancer

date 18 hours ago

Intermittent dosing with rapamycin selectively breaks the cascade of inflammatory events that follow cellular senescence, a phenomena in which cells cease to divide in response to DNA damaging agents, including ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.