Soy linked to exacerbated congenital hypothyroidism

August 20, 2012
Soy linked to exacerbated congenital hypothyroidism
Soy products appear to interfere with levothyroxine absorption and can exacerbate congenital hypothyroidism in infants and young children, according to a case report published online Aug. 20 in Pediatrics.

(HealthDay) -- Soy products appear to interfere with levothyroxine absorption and can exacerbate congenital hypothyroidism in infants and young children, according to a case report published online Aug. 20 in Pediatrics.

Abigail Gelb Fruzza, M.D., from the University of California San Diego in La Jolla, and colleagues observed two with who continued to manifest clinical while receiving recommended doses of hormone and ingesting soy products.

The researchers found that the first patient (diagnosed by newborn screening showing thyroid-stimulating hormone [TSH] of 169 µIU/mL and treated with 50 µg of since 6 days of age while simultaneously starting soy formula) was clinically and biochemically hypothyroid (thyroxine, 4.0 µg/dL; TSH, 216 µIU/mL) at 3 weeks of age. After stopping her soy formula and decreasing her levothyroxine, signs of hypothyroidism had begun resolving three weeks later. By 10 weeks of age, she was clinically and biochemically euthyroid. Another patient, diagnosed by , received levothyroxine and did well; however, over the next two years she began consuming soy milk and became profoundly hypothyroid (free thyroxine, <0.4 ng/dL; TSH, 248 µIU/mL), even with an increase in her levothyroxine dose to 112 µg/day. After switching to cow milk, her thyroid function slowly normalized with decreasing doses of levothyroxine.

"These two patients reinforce the importance of remembering that soy products interfere with levothyroxine absorption and can endanger infants and young children with congenital hypothyroidism who are at risk for developmental and growth delay," the authors write.

Explore further: Screening adults for hypothyroidism could give 100,000 'a new lease of life'

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Recommended for you

Some youth football drills riskier than others

August 23, 2016

Nearly three quarters of the football players in the U.S. are less than 14 years old. But amid growing concern about concussion risk in football, the majority of the head-impact research has focused on college and professional ...

Babies often put to sleep in unsafe positions

August 15, 2016

(HealthDay)—Despite decades of warnings from the "Back to Sleep" campaign, many parents are still putting their babies to sleep in ways that raise the risk of sudden infant death syndrome (SIDS), a new study finds.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.