Soy linked to exacerbated congenital hypothyroidism

Soy linked to exacerbated congenital hypothyroidism
Soy products appear to interfere with levothyroxine absorption and can exacerbate congenital hypothyroidism in infants and young children, according to a case report published online Aug. 20 in Pediatrics.

(HealthDay) -- Soy products appear to interfere with levothyroxine absorption and can exacerbate congenital hypothyroidism in infants and young children, according to a case report published online Aug. 20 in Pediatrics.

Abigail Gelb Fruzza, M.D., from the University of California San Diego in La Jolla, and colleagues observed two with who continued to manifest clinical while receiving recommended doses of hormone and ingesting soy products.

The researchers found that the first patient (diagnosed by newborn screening showing thyroid-stimulating hormone [TSH] of 169 µIU/mL and treated with 50 µg of since 6 days of age while simultaneously starting soy formula) was clinically and biochemically hypothyroid (thyroxine, 4.0 µg/dL; TSH, 216 µIU/mL) at 3 weeks of age. After stopping her soy formula and decreasing her levothyroxine, signs of hypothyroidism had begun resolving three weeks later. By 10 weeks of age, she was clinically and biochemically euthyroid. Another patient, diagnosed by , received levothyroxine and did well; however, over the next two years she began consuming soy milk and became profoundly hypothyroid (free thyroxine, <0.4 ng/dL; TSH, 248 µIU/mL), even with an increase in her levothyroxine dose to 112 µg/day. After switching to cow milk, her thyroid function slowly normalized with decreasing doses of levothyroxine.

"These two patients reinforce the importance of remembering that soy products interfere with levothyroxine absorption and can endanger infants and young children with congenital hypothyroidism who are at risk for developmental and growth delay," the authors write.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Neonatal vitamin K refusal tied to nonimmunization

Aug 20, 2014

(HealthDay)—While neonatal vitamin K refusal is rare, parents who refuse vitamin K are less likely to immunize their child, according to a study published online Aug. 18 in Pediatrics.

Teen sleeplessness piles on risk for obesity

Aug 20, 2014

Teenagers who don't get enough sleep may wake up to worse consequences than nodding off during chemistry class. According to new research, risk of being obese by age 21 was 20 percent higher among 16-year-olds who got less ...

Researchers show economic disparities impact infant health

Aug 20, 2014

Women who are poor experience higher cortisol levels in pregnancy and give birth to infants with elevated levels of the stress hormone, putting them at greater risk for serious disease later in life, according to a new research ...

User comments