In this week's PLOS Medicine, Anna Borquez from Imperial College London and an international group of authors developed a mathematical model representing the HIV epidemic among men who have sex with men (MSM) and transwomen in Lima, Peru as a test-case for the effectiveness of HIV pre-exposure prophylaxis (PrEP).
The model was used to investigate the population-level impact, cost, and cost-effectiveness of PrEP under a range of different scenarios.
The authors found that strategic PrEP intervention could be a cost-effective addition to existing HIV prevention strategies for MSM populations.
However, despite being cost-effective, a substantial expenditure would be required to generate significant reductions in incidence of HIV.
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Gomez GB, Borquez A, Caceres CF, Segura ER, Grant RM, et al. (2012) The Potential Impact of Pre-Exposure Prophylaxis for HIV Prevention among Men Who Have Sex with Men and Transwomen in Lima, Peru: A Mathematical Modelling Study. PLoS Med 9(10): e1001323. doi:10.1371/journal.pmed.1001323