Pre-op factors predict post-gastric op glycemic response

Pre-op factors predict post-gastric op glycemic response
The glycemic response to gastric bypass surgery can be predicted in Chinese patients with type 2 diabetes by three preoperative factors, according to a study published online Oct. 1 in Diabetes Care.

(HealthDay)—The glycemic response to gastric bypass surgery can be predicted in Chinese patients with type 2 diabetes by three preoperative factors, according to a study published online Oct. 1 in Diabetes Care.

John B. Dixon, Ph.D., from the Baker IDI Heart & Diabetes Institute in Melbourne, Australia, and colleagues analyzed preoperative details of 154 with to identify clinically meaningful predictors of diabetes remission after gastric . A hemoglobin A1c level of ≤6 percent was used to define remission.

The researchers found that, at 12 months, 69.5 percent of participants achieved remission. The three independent preoperative predictors were: diabetes duration of less than four years, body mass index above 35 kg/m², and fasting C-peptide concentration of more than 2.9 ng/mL. Using two or three of these predictors allowed a sensitivity of 82 percent and specificity of 87 percent for remission. Those cases in which hemoglobin A1c ≤7 percent was not achieved were predicted by duration of diabetes and C-peptide. Remission and less satisfactory outcomes were also predicted by percentage of weight loss after surgery.

"The glycemic response to gastric bypass is related to body mass index, duration of , fasting C-peptide (influenced by insulin resistance and residual β-cell function), and weight loss," the authors write. "These data support and refine previous findings in non-Asian populations. Specific ethnic and procedural regression equations and cutoff points may vary."

Several authors or their institutions disclosed financial ties to the pharmaceutical and medical device industries.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Scientists reassess weight loss surgery for type 2 diabetes

Jan 04, 2012

Weight loss surgery is not a cure for type 2 diabetes, but it can improve blood sugar control, according to a new study published in the British Journal of Surgery. Whereas some previous studies have claimed that up to 80 ...

Race might play role in success of weight-loss surgery

Jun 20, 2012

(HealthDay) -- Black women without diabetes lost about 10 percent less weight than white women after having a weight-loss procedure called gastric bypass surgery, but having diabetes helped increase their ...

Recommended for you

Shift work linked to heightened risk of type 2 diabetes

Jul 24, 2014

Shift work is linked to a heightened risk of developing type 2 diabetes, with the risk seemingly greatest among men and those working rotating shift patterns, indicates an analysis of the available evidence published online ...

Rosemary and oregano contain diabetes-fighting compounds

Jul 23, 2014

The popular culinary herbs oregano and rosemary are packed with healthful compounds, and now lab tests show they could work in much the same way as prescription anti-diabetic medication, scientists report. In their new study ...

User comments