Metformin treatment beneficial for obese children, teens

Metformin treatment beneficial for obese children, teens
Obese children and adolescents treated with twice-daily metformin have significantly improved body mass index standard deviation scores, fasting glucose, and other metabolic risk factors, according to research published online Nov. 21 in the Journal of Clinical Endocrinology & Metabolism.

(HealthDay)—Obese children and adolescents treated with twice-daily metformin have significantly improved body mass index standard deviation scores (BMI-SDS), fasting glucose, and other metabolic risk factors, according to research published online Nov. 21 in the Journal of Clinical Endocrinology & Metabolism.

Deborah Kendall, M.D., of the Royal Manchester Children's Hospital in the United Kingdom, and colleagues conducted a prospective, randomized, double-blind, placebo-controlled trial involving 151 obese children and adolescents from six pediatric endocrine centers to evaluate the effect of metformin, given at a dose of 1 g each morning and 500 mg each evening. Seventy-four participants were allocated to metformin and 77 were assigned to placebo for six months.

At three months, the researchers found that metformin-treated children and adolescents had significantly improved levels, alanine aminotransferase (ALT) levels, and adiponectin to leptin ratios (ALR) compared with placebo-treated participants. At six months, there were significant changes in BMI-SDS in metformin-treated participants compared with those who received placebo.

"The MOCA [Metformin in and Adolescents] trial provides evidence that a short treatment course of metformin is clinically useful, safe, and well tolerated to halt further gain in adiposity and improve fasting glucose, ALT, and ALR," the authors write. "Metformin may also provide a stimulus for further lifestyle changes and is a useful adjunct to support lifestyle modification and potentially reduce long-term risk of cardiovascular disease and type 2 diabetes."

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Imeglimin beneficial as add-on to metformin in T2DM

Dec 14, 2012

(HealthDay)—For patients with type 2 diabetes inadequately controlled by metformin alone, addition of the new oral anti-diabetes agent imeglimin improves glycemic control with good tolerability and safety, ...

Metformin may have dual effect in breast cancer

May 09, 2012

(HealthDay) -- For women without diabetes and with operable breast cancer, administration of metformin prior to surgery does not significantly affect the proliferative marker Ki-67 overall, but drug effects ...

Recommended for you

Cerebral palsy may be hereditary

4 hours ago

Cerebral palsy is a neurological developmental disorder which follows an injury to the immature brain before, during or after birth. The resulting condition affects the child's ability to move and in some ...

19 new dengue cases in Japan, linked to Tokyo park

10 hours ago

Japan is urging local authorities to be on the lookout for further outbreaks of dengue fever, after confirming another 19 cases that were contracted at a popular local park in downtown Tokyo.

User comments