Low testosterone levels affect total lipid oxidation
December 7, 2012 in Medical research
Very low testosterone levels impact total lipid oxidation but have no effect on the production of very-low-density lipoprotein-triglycerides, according to a study published online Nov. 27 in Diabetes.
(HealthDay)—Very low testosterone levels impact total lipid oxidation but have no effect on the production of very-low-density lipoprotein-triglycerides (VLDL-TGs), according to a study published online Nov. 27 in Diabetes.
Christian Høst, from the Aarhus University Hospital in Denmark, and colleagues treated 12 healthy young males (mean age, 23.1 years) with a gonadotropin-releasing hormone agonist to induce castration levels of testosterone. Over several days one month later, the men were randomly treated with a gel containing physiological levels of testosterone, supraphysiological levels of testosterone, and placebo as part of a crossover study.
The researchers found that short-term hypogonadism had no effect on the secretion or concentration of VLDL-TGs but was characterized by reduced total lipid oxidation. High physiological testosterone levels increased VLDL-TG secretion under both basal conditions and after application of a hyperinsulinemic-euglycemic clamp.
"These data show that testosterone can act through fast non-genomic pathways in the liver," Høst and colleagues conclude. "Testosterone is not a major determinant of resting VLDL-TG kinetics in men."
The study was funded in part by an unconditional research grant from Ipsen Pharma. Two authors disclosed financial ties to the pharmaceutical industry.
More information: Abstract
Full Text (subscription or payment may be required)
Journal reference:
Diabetes
Copyright © 2012 HealthDay. All rights reserved.
-
Overweight men can boost low testosterone levels by losing weight
Jun 25, 2012 |
not rated yet |
0
-
Older age does not cause testosterone levels to decline in healthy men
Jun 07, 2011 |
not rated yet |
0
-
High testosterone may mean shorter lives
Apr 13, 2006 |
not rated yet |
0
-
Testosterone Decreases after Ingestion of Sugar
Jun 14, 2009 |
not rated yet |
0
-
Low testosterone appears to increase long-term risk of death
Jun 17, 2008 |
not rated yet |
0
-
Motion perception revisited: High Phi effect challenges established motion perception assumptions
Apr 23, 2013 |
3 / 5 (2) |
2
-
Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update)
Apr 02, 2013 |
4.5 / 5 (11) |
5
-
The visual system as economist: Neural resource allocation in visual adaptation
Mar 30, 2013 |
5 / 5 (2) |
9
-
Separate lives: Neuronal and organismal lifespans decoupled
Mar 27, 2013 |
4.9 / 5 (8) |
0
-
Sizing things up: The evolutionary neurobiology of scale invariance
Feb 28, 2013 |
4.8 / 5 (10) |
14
-
Why is zone 1 in liver more prone to ischemic injury?
14 hours ago
-
How can there be villous adenoma in colon, if there are no villi there
May 22, 2013
-
How can there be a term called "intestinal metaplasia" of stomach
May 21, 2013
-
Pressure-volume curve: Elastic Recoil Pressure don't make sense
May 18, 2013
-
If you became brain-dead, would you want them to pull the plug?
May 17, 2013
-
MRI bill question
May 15, 2013
- More from Physics Forums - Medical Sciences
More news stories
Study reveals new mechanism for estrogen suppression of liver lipid synthesis
By discovering the new mechanism by which estrogen suppresses lipid synthesis in the liver, UC Irvine endocrinologists have revealed a potential new approach toward treating certain liver diseases.
Medical research
2 hours ago |
not rated yet |
0
|
MRI-based measurement helps predict vascular disease in the brain
Aortic arch pulse wave velocity, a measure of arterial stiffness, is a strong independent predictor of disease of the vessels that supply blood to the brain, according to a new study published in the June issue the journal ...
Medical research
2 hours ago |
not rated yet |
0
Antibiotics: A new understanding of sulfonamide nervous system side effects
Since the discovery of Prontosil in 1932, sulfonamide antibiotics have been used to combat a wide spectrum of bacterial infections, from acne to chlamydia and pneumonia. However, their side effects can include serious neurological ...
Medical research
4 hours ago |
not rated yet |
0
|
Scientists discover molecule triggers sensation of itch
Scientists at the National Institutes of Health report they have discovered in mouse studies that a small molecule released in the spinal cord triggers a process that is later experienced in the brain as ...
Medical research
4 hours ago |
5 / 5 (2) |
0
|
Discarded immune cells induce the relocation of stem cells
Spanish researchers have discovered that the daily clearance of neutrophils from the body stimulates the release of hematopoietic stem cells from the bone marrow into the bloodstream, according to a report published today ...
Medical research
6 hours ago |
5 / 5 (2) |
0
Controlling mood through the motions of mitochondria
(Medical Xpress)—Regulating the distribution of power in neurons is done by a system that makes the national electric grid look simple by comparison. Each neuron has several thousand mitochondria confined ...
Statin use is linked to increased risk of developing diabetes, warn researchers
Treatment with high potency statins (especially atorvastatin and simvastatin) may increase the risk of developing diabetes, suggests a paper published today in BMJ.
Consumers largely underestimating calorie content of fast food
People eating at fast food restaurants largely underestimate the calorie content of meals, especially large ones, according to a paper published today in BMJ.
Future doctors unaware of their obesity bias
Two out of five medical students have an unconscious bias against obese people, according to a new study by researchers at Wake Forest Baptist Medical Center. The study is published online ahead of print in the Journal of ...
WHO: Scientific red tape mars efforts vs. virus
International efforts to combat a new pneumonia-like virus that has now killed 22 people are being slowed by unclear rules and competition for the potentially profitable rights to disease samples, the head ...
Research identifies a way to make cancer cells more responsive to chemotherapy
Breast cancer characterized as "triple negative" carries a poor prognosis, with limited treatment options. In some cases, chemotherapy doesn't kill the cancer cells the way it's supposed to. New research from Western University ...
