Chronic kidney disease increases risk of death for both women and men

January 30, 2013

A new study from the Johns Hopkins Bloomberg School of Public Health and the Chronic Kidney Disease Prognosis Consortium (CKD-PC) found that in general chronic kidney disease is similarly associated with a higher risk of death and end stage renal disease for both women and men. The findings were released online in advance of publication in BMJ.

affects 10 to 16 percent of adults worldwide. Current thresholds for chronic kidney disease are based on two kidney measures, estimated (GFR) and albuminuria, a measure of protein in the urine. Because mildly reduced GFR is more common in women, and both kidney measures are affected by muscle mass, some have suggested that the definition of chronic kidney disease should be sex-specific.

According to the study, the overall risks of all-cause mortality and were higher in men at all levels of . However, both sexes experienced increased risks of all-cause mortality, cardiovascular mortality, and end stage renal disease with lower estimated glomerular filtration rate and higher albuminuria, with only a slight difference in the strength of relationships between sexes.

"Our results contrast with some previous studies suggesting that the association of estimated glomerular filtration rate with mortality is weaker in women. We found the association between chronic kidney disease and to be as strong in women as in men. Low estimated glomerular filtration rate or albuminuria should be considered at least as potent a risk factor in women as it is in men," said Josef Coresh, MD, PhD, MHS, the Consortium's principal investigator and professor in the Bloomberg School's Department of Epidemiology.

For the study, researchers analyzed data from more than 2 million participants from 46 cohort studies. The included a diverse population from Asia, Australia, Europe, and North and South America. Fifty-four percent of the study populations were women.

"Associations of estimated glomerular filtration rate and albuminuria with mortality and renal failure by sex: a meta-analysis" was written by the CKD-PC, which includes approximately 200 collaborators and data from 40 countries.

Explore further: Study finds a better method for diagnosing kidney disease

Related Stories

Study finds a better method for diagnosing kidney disease

May 8, 2012

Assessing glomerular filtration rate (GFR) using kidney filtration markers in blood is the standard means for determining kidney function, diagnosing kidney disease and measuring its progression. A higher filtration rate ...

Chronic kidney disease increases risk of death at all ages

October 31, 2012

A new study from the Johns Hopkins Bloomberg School of Public Health and the Chronic Kidney Disease Prognosis Consortium found that chronic kidney disease and its complications were associated with a higher risk of death ...

Recommended for you

Kidney stone? Try a roller coaster ride

September 27, 2016

(HealthDay)—Anyone who's suffered a kidney stone just wants the urinary obstruction gone. Now, preliminary research suggests relief might even be fun: a roller coaster ride.

The 'love hormone' may quiet tinnitus

September 23, 2016

(HealthDay)—People suffering from chronic ringing in the ears—called tinnitus—may find some relief by spraying the hormone oxytocin in their nose, a small initial study by Brazilian researchers suggests.

Bile acid uptake inhibitor prevents NASH / fatty liver in mice

September 21, 2016

Drugs that interfere with bile acid recycling can prevent several aspects of NASH (nonalcoholic steatohepatitis) in mice fed a high-fat diet, scientists from Emory University School of Medicine and Children's Healthcare of ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.