Accelerated cognitive decline seen with T2DM in middle age

January 21, 2013
Accelerated cognitive decline seen with T2DM in middle age
Middle-aged patients with type 2 diabetes show accelerated cognitive decline in information processing speed and executive function, according to a study published online Dec. 28 in Diabetes Care.

(HealthDay)—Middle-aged patients with type 2 diabetes show accelerated cognitive decline in information processing speed and executive function, according to a study published online Dec. 28 in Diabetes Care.

To examine the effects of baseline and incident diabetes on cognitive function, Peggy J.J. Spauwen, from Maastricht University in the Netherlands, and colleagues conducted cognitive testing on 1,290 individuals (40 years or older) participating in the Maastricht Aging Study. Testing was performed at baseline and at six and 12 years.

At baseline, 68 participants had type 2 diabetes, while 54 and 57 had incident diabetes at the six- and 12-year follow-up, respectively. Over the 12-year follow-up, the researchers identified significantly larger decline in information-processing speed, executive function, and delayed word recall among those with diabetes at baseline, compared with control subjects. There was no significant difference noted in the decline for immediate word recall. Participants with incident diabetes showed subtle early decrease in information-processing speed only, compared to the controls; however, in other cognitive domains there was no larger decline observed.

"It seems that disease-exposure time plays an important role in the development of . This might provide a window of opportunity for prevention and early treatment of diabetes-related cognitive deficits," the authors write. "For this, it is important to assess at an early stage of the disease and on a regular basis."

Explore further: Irregular heartbeat strong predictor of decline in people at risk of heart disease

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Mindfulness-based cognitive therapy beneficial in diabetes

December 11, 2012

(HealthDay)—For patients with diabetes and low levels of emotional well-being, mindfulness-based cognitive therapy (MBCT) improves emotional distress and health-related quality of life, according to a study published online ...

Recommended for you

Do germs cause type 1 diabetes?

May 16, 2016

Germs could play a role in the development of type 1 diabetes by triggering the body's immune system to destroy the cells that produce insulin, new research suggests.

Melatonin signaling is a risk factor for type 2 diabetes

May 12, 2016

A sleeping pancreas releases less insulin, but how much insulin drops each night may differ from person to person, suggests a study published May 12, 2016 in Cell Metabolism. Up to 30 percent of the population may be predisposed ...

New gene for familial high cholesterol

May 12, 2016

New research from Denmark reveals the gene that explains one quarter of all familial hypercholesterolemia with very high blood cholesterol. Familial hypercholesterolemia is the most common genetic disorder leading to premature ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.