Exposure to COI policies during residency reduces rate of brand antidepressant prescriptions

Psychiatrists who are exposed to conflict-of-interest (COI) policies during their residency are less likely to prescribe brand-name antidepressants after graduation than those who trained in residency programs without such policies, according to a new study by researchers from the Perelman School of Medicine at the University of Pennsylvania. The study is the first of its kind to show that exposure to COI policies for physicians during residency training – in this case, psychiatrists – is effective in lowering their post-graduation rates of prescriptions for brand medications, including heavily promoted and brand reformulated antidepressants. Full results of the study will be published in the February issue of Medical Care and are now available online.

"Our study focuses on because they have been among the most heavily marketed drug classes," said Andrew J. Epstein, PhD, research associate professor of Medicine at the Perelman School of Medicine at the University of Pennsylvania, and first author on the study. "Data show that antidepressant use increased nearly 400 percent from 1988 to 2008. The goal for this study was to determine whether exposure to COI policies during residency would influence psychiatrists' antidepressant prescribing patterns after graduation."

In recent years, as a result of the dramatic increase in prescription , relationships between pharmaceutical representatives and have come under extensive scrutiny both within the medical profession and by policy makers. Penn Medicine in 2006 implemented policies placing restrictions on physician interactions with pharmaceutical representatives. In 2008, the Association of American Medical Colleges developed COI policy guidelines for gifts, free meals, and medication samples provided by pharmaceutical representatives to physicians and trainees. The concern was that these interactions could influence clinicians to prescribe brand medications even if they were more expensive or less suitable for patients than generic alternatives.

To assess the effects of COI policies on physicians' prescribing patterns after residency, the research team examined 2009 prescribing data from IMS Health for 1,652 from 162 residency programs. The physicians fell into two categories: about half graduated residency in 2001, before COI training guidelines were implemented, while the other half graduated residency in 2008, after many medical centers adopted COI policies. Physicians were also categorized based on the restrictiveness of the COI policies adopted by their residency programs' medical centers. Results of the study show that, although rates of prescribing brand antidepressants, including those that were heavily promoted and brand reformulations, were lower among 2008 graduates than 2001 graduates in general, the rates were lowest for 2008 graduates of residency programs with very restrictive COI policies.

The results suggest that COI policies reduce the appeal of antidepressant medications marketed heavily by pharmaceutical companies. Because brand-name medications tend to be more expensive, Epstein says a shift away from them could help reduce cost growth. However, he cautions that lower costs achieved through stringent COI policies may come at a price.

"Contact with the pharmaceutical industry may have important informational benefits for physicians. And, by exposing trainees to industry representatives, we may be helping them prepare to navigate these relationships after graduation," said Epstein. "Nevertheless, while these relationships may be useful in some ways, our study clearly shows that implementation of COI policies have helped shield physicians from the often persuasive aspects of pharmaceutical promotion."

The study provides the first empirical evidence of the effects of COI policies, specifically pertaining to antidepressants. Epstein notes that in future research it will be critical to assess whether these policies have similar effects on other drug classes and physician specialties.

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Some people may be pre-wired to be bilingual

8 hours ago

(HealthDay)—Some people's brains seem pre-wired to acquire a second language, new research suggests. But anyone who tries to move beyond their mother tongue will likely gain a brain boost, the small study ...

Elderly brains learn, but maybe too much

17 hours ago

A new study led by Brown University reports that older learners retained the mental flexibility needed to learn a visual perception task but were not as good as younger people at filtering out irrelevant ...

Inpatient psychotherapy is effective in Germany

20 hours ago

Sarah Liebherz (Department of Medical Psychology, University Medical Centre Hamburg-Eppendorf) and Sven Rabung (Institute of Psychology, Alpen-Adria-Universität Klagenfurt) have examined 59 studies conducted between 1977 ...

A game changer to boost literacy and maths skills

21 hours ago

(Medical Xpress)—Finding the best way to teach reading has been an ongoing challenge for decades, especially for those children in underprivileged areas who fail to learn to read. What is the magic ingredient that will ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.